Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease.

Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease.

<h4>Background and aim</h4>Alcohol-related liver disease (ALD) remains a leading cause of liver-related morbidity and mortality. Age, fibrosis stage, MELD score and continued alcohol consumption predict outcome in everyday clinical practice. In previous studies increased hepatocyte nucle...

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Autores principales: Aloysious Aravinthan, Giada Pietrosi, Matthew Hoare, James Jupp, Aileen Marshall, Clare Verrill, Susan Davies, Adrian Bateman, Nick Sheron, Michael Allison, Graeme J M Alexander
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/f7baa89d77754508aaf5a78aa3fd829b
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