The anti-viral dynamin family member MxB participates in mitochondrial integrity

Mx proteins belong to the dynamin family of large GTPases and are highly induced by interferon in virally infected cells. The authors show that uninfected immune cells and hepatocytes also express MxB protein that associates with mitochondria to alter the morphology and genome of this organelle.

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Autores principales: Hong Cao, E. W. Krueger, Jing Chen, Kristina Drizyte-Miller, Mary E. Schulz, Mark A. McNiven
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f7bc8160d7f84107957d916022d0b4ee
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Sumario:Mx proteins belong to the dynamin family of large GTPases and are highly induced by interferon in virally infected cells. The authors show that uninfected immune cells and hepatocytes also express MxB protein that associates with mitochondria to alter the morphology and genome of this organelle.