Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries

Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological evidence indicated that CHIKV first emerged in 1954. From the 1950’s to 2005, sporadic CHIKV infections were attr...

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Autores principales: Sarawut Khongwichit, Jira Chansaenroj, Chintana Chirathaworn, Yong Poovorawan
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Lenguaje:EN
Publicado: BMC 2021
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spelling oai:doaj.org-article:f7bde2fe3db64002a5ab802e05c610632021-12-05T12:10:35ZChikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries10.1186/s12929-021-00778-81423-0127https://doaj.org/article/f7bde2fe3db64002a5ab802e05c610632021-12-01T00:00:00Zhttps://doi.org/10.1186/s12929-021-00778-8https://doaj.org/toc/1423-0127Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological evidence indicated that CHIKV first emerged in 1954. From the 1950’s to 2005, sporadic CHIKV infections were attributed to the Asian genotype. However, the massive outbreak of CHIKV in India and the Southwest Indian Ocean Islands in 2005 has since raised chikungunya as a worldwide public health concern. The virus is spreading globally, but mostly in tropical and subtropical regions, particularly in South and Southeast Asia. The emergence of the CHIKV East/Central/South African genotype-Indian Ocean lineage (ECSA-IOL) has caused large outbreaks in South and Southeast Asia affected more than a million people over a decade. Notably, the massive CHIKV outbreaks before 2016 and the more recent outbreak in Asia were driven by distinct ECSA lineages. The first significant CHIKV ECSA strains harbored the Aedes albopictus-adaptive mutation E1: A226V. More recently, another mass CHIKV ECSA outbreak in Asia started in India and spread beyond South and Southeast Asia to Kenya and Italy. This virus lacked the E1: A226V mutation but instead harbored two novel mutations (E1: K211E and E2: V264A) in an E1: 226A background, which enhanced its fitness in Aedes aegypti. The emergence of a novel ECSA strain may lead to a more widespread geographical distribution of CHIKV in the future. This review summarizes the current CHIKV situation in Asian countries and provides a general overview of the molecular virology, disease manifestation, diagnosis, prevalence, genotype distribution, evolutionary relationships, and epidemiology of CHIKV infection in Asian countries over the past 65 years. This knowledge is essential in guiding the epidemiological study, control, prevention of future CHIKV outbreaks, and the development of new vaccines and antivirals targeting CHIKV.Sarawut KhongwichitJira ChansaenrojChintana ChirathawornYong PoovorawanBMCarticleChikungunya virusOutbreakAsiaNovel ECSAE1: K211E and E2: V264AMedicineRENJournal of Biomedical Science, Vol 28, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chikungunya virus
Outbreak
Asia
Novel ECSA
E1: K211E and E2: V264A
Medicine
R
spellingShingle Chikungunya virus
Outbreak
Asia
Novel ECSA
E1: K211E and E2: V264A
Medicine
R
Sarawut Khongwichit
Jira Chansaenroj
Chintana Chirathaworn
Yong Poovorawan
Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
description Abstract Chikungunya virus (CHIKV) is a re-emerging mosquito-borne human pathogen that causes chikungunya fever, which is typically accompanied by severe joint pain. In Asia, serological evidence indicated that CHIKV first emerged in 1954. From the 1950’s to 2005, sporadic CHIKV infections were attributed to the Asian genotype. However, the massive outbreak of CHIKV in India and the Southwest Indian Ocean Islands in 2005 has since raised chikungunya as a worldwide public health concern. The virus is spreading globally, but mostly in tropical and subtropical regions, particularly in South and Southeast Asia. The emergence of the CHIKV East/Central/South African genotype-Indian Ocean lineage (ECSA-IOL) has caused large outbreaks in South and Southeast Asia affected more than a million people over a decade. Notably, the massive CHIKV outbreaks before 2016 and the more recent outbreak in Asia were driven by distinct ECSA lineages. The first significant CHIKV ECSA strains harbored the Aedes albopictus-adaptive mutation E1: A226V. More recently, another mass CHIKV ECSA outbreak in Asia started in India and spread beyond South and Southeast Asia to Kenya and Italy. This virus lacked the E1: A226V mutation but instead harbored two novel mutations (E1: K211E and E2: V264A) in an E1: 226A background, which enhanced its fitness in Aedes aegypti. The emergence of a novel ECSA strain may lead to a more widespread geographical distribution of CHIKV in the future. This review summarizes the current CHIKV situation in Asian countries and provides a general overview of the molecular virology, disease manifestation, diagnosis, prevalence, genotype distribution, evolutionary relationships, and epidemiology of CHIKV infection in Asian countries over the past 65 years. This knowledge is essential in guiding the epidemiological study, control, prevention of future CHIKV outbreaks, and the development of new vaccines and antivirals targeting CHIKV.
format article
author Sarawut Khongwichit
Jira Chansaenroj
Chintana Chirathaworn
Yong Poovorawan
author_facet Sarawut Khongwichit
Jira Chansaenroj
Chintana Chirathaworn
Yong Poovorawan
author_sort Sarawut Khongwichit
title Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
title_short Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
title_full Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
title_fullStr Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
title_full_unstemmed Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries
title_sort chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in asian countries
publisher BMC
publishDate 2021
url https://doaj.org/article/f7bde2fe3db64002a5ab802e05c61063
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AT chintanachirathaworn chikungunyavirusinfectionmolecularbiologyclinicalcharacteristicsandepidemiologyinasiancountries
AT yongpoovorawan chikungunyavirusinfectionmolecularbiologyclinicalcharacteristicsandepidemiologyinasiancountries
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