Survival in influenza virus-related pneumonia by viral subtype: 2016-2020

Background: : Influenza remains a common cause of morbidity and mortality worldwide, and viral subtype-related differences in disease outcomes have been documented. Objective: : To characterize the survival experience of adult inpatients with influenza virus-associated pneumonia by viral subtype dur...

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Autores principales:	Efrén Murillo-Zamora, Xóchitl Trujillo, Miguel Huerta, Mónica Ríos-Silva, José Guzmán-Esquivel, Verónica Benites-Godínez, Oliver Mendoza-Cano
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Influenza, Human Survival Rate Inpatients Pneumonia, Viral Proportional Hazards Models Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f7c10cb7038a474396fa7113c47a76cf
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spelling	oai:doaj.org-article:f7c10cb7038a474396fa7113c47a76cf2021-11-30T04:14:19ZSurvival in influenza virus-related pneumonia by viral subtype: 2016-20201201-971210.1016/j.ijid.2021.09.037https://doaj.org/article/f7c10cb7038a474396fa7113c47a76cf2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007438https://doaj.org/toc/1201-9712Background: : Influenza remains a common cause of morbidity and mortality worldwide, and viral subtype-related differences in disease outcomes have been documented. Objective: : To characterize the survival experience of adult inpatients with influenza virus-associated pneumonia by viral subtype during five consecutive flu seasons. Method: : We performed a retrospective cohort study; data from 4,678 adults were analyzed using the Kaplan-Meier method. A multivariate Cox proportional hazard regression model was fitted. Results: : The overall in-hospital mortality rate was 25.0 per 1,000 hospital days. The survival probabilities from pneumonia patients went from 93.4% (95% CI 92.6-94.1%) by day three to 43.3% (95% CI 39.2-47.4%) by day 30 from hospital admission. In general, the lowest survival rates were observed in patients with AH1N1 infection. In multiple models, after adjusting for comorbidities and when compared with A non-subtyped virus, pneumonia patients with AH3N2 or B strains had a significantly decreased risk of a non-favorable disease outcome. The association of other strains was not significant. Conclusions: : Our findings suggest that the survival of inpatients with influenza virus-associated pneumonia varies according to the pathogenic viral subtype; the lowest survival rates were observed in patients with AH1N1 infection. This effect was independent of the patients' gender, age, and the analyzed underlying health conditions.Efrén Murillo-ZamoraXóchitl TrujilloMiguel HuertaMónica Ríos-SilvaJosé Guzmán-EsquivelVerónica Benites-GodínezOliver Mendoza-CanoElsevierarticleInfluenza, HumanSurvival RateInpatientsPneumonia, ViralProportional Hazards ModelsInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 288-293 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Influenza, Human Survival Rate Inpatients Pneumonia, Viral Proportional Hazards Models Infectious and parasitic diseases RC109-216
spellingShingle	Influenza, Human Survival Rate Inpatients Pneumonia, Viral Proportional Hazards Models Infectious and parasitic diseases RC109-216 Efrén Murillo-Zamora Xóchitl Trujillo Miguel Huerta Mónica Ríos-Silva José Guzmán-Esquivel Verónica Benites-Godínez Oliver Mendoza-Cano Survival in influenza virus-related pneumonia by viral subtype: 2016-2020
description	Background: : Influenza remains a common cause of morbidity and mortality worldwide, and viral subtype-related differences in disease outcomes have been documented. Objective: : To characterize the survival experience of adult inpatients with influenza virus-associated pneumonia by viral subtype during five consecutive flu seasons. Method: : We performed a retrospective cohort study; data from 4,678 adults were analyzed using the Kaplan-Meier method. A multivariate Cox proportional hazard regression model was fitted. Results: : The overall in-hospital mortality rate was 25.0 per 1,000 hospital days. The survival probabilities from pneumonia patients went from 93.4% (95% CI 92.6-94.1%) by day three to 43.3% (95% CI 39.2-47.4%) by day 30 from hospital admission. In general, the lowest survival rates were observed in patients with AH1N1 infection. In multiple models, after adjusting for comorbidities and when compared with A non-subtyped virus, pneumonia patients with AH3N2 or B strains had a significantly decreased risk of a non-favorable disease outcome. The association of other strains was not significant. Conclusions: : Our findings suggest that the survival of inpatients with influenza virus-associated pneumonia varies according to the pathogenic viral subtype; the lowest survival rates were observed in patients with AH1N1 infection. This effect was independent of the patients' gender, age, and the analyzed underlying health conditions.
format	article
author	Efrén Murillo-Zamora Xóchitl Trujillo Miguel Huerta Mónica Ríos-Silva José Guzmán-Esquivel Verónica Benites-Godínez Oliver Mendoza-Cano
author_facet	Efrén Murillo-Zamora Xóchitl Trujillo Miguel Huerta Mónica Ríos-Silva José Guzmán-Esquivel Verónica Benites-Godínez Oliver Mendoza-Cano
author_sort	Efrén Murillo-Zamora
title	Survival in influenza virus-related pneumonia by viral subtype: 2016-2020
title_short	Survival in influenza virus-related pneumonia by viral subtype: 2016-2020
title_full	Survival in influenza virus-related pneumonia by viral subtype: 2016-2020
title_fullStr	Survival in influenza virus-related pneumonia by viral subtype: 2016-2020
title_full_unstemmed	Survival in influenza virus-related pneumonia by viral subtype: 2016-2020
title_sort	survival in influenza virus-related pneumonia by viral subtype: 2016-2020
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f7c10cb7038a474396fa7113c47a76cf
work_keys_str_mv	AT efrenmurillozamora survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020 AT xochitltrujillo survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020 AT miguelhuerta survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020 AT monicariossilva survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020 AT joseguzmanesquivel survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020 AT veronicabenitesgodinez survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020 AT olivermendozacano survivalininfluenzavirusrelatedpneumoniabyviralsubtype20162020
_version_	1718406840596824064

Survival in influenza virus-related pneumonia by viral subtype: 2016-2020

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