Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.

<h4>Background</h4>Severe acute respiratory illness (SARI) is an important cause of mortality in young children, especially in children living with HIV infection. Disparities in SARI death in children aged <5 years exist in urban and rural areas.<h4>Objective</h4>To compar...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Oluwatosin A Ayeni, Sibongile Walaza, Stefano Tempia, Michelle Groome, Kathleen Kahn, Shabir A Madhi, Adam L Cohen, Jocelyn Moyes, Marietjie Venter, Marthi Pretorius, Florette Treurnicht, Orienka Hellferscee, Anne von Gottberg, Nicole Wolter, Cheryl Cohen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/f7c43c6a80194567beb9a9fdcabd7b8f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f7c43c6a80194567beb9a9fdcabd7b8f
record_format dspace
spelling oai:doaj.org-article:f7c43c6a80194567beb9a9fdcabd7b8f2021-12-02T20:18:16ZMortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.1932-620310.1371/journal.pone.0255941https://doaj.org/article/f7c43c6a80194567beb9a9fdcabd7b8f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255941https://doaj.org/toc/1932-6203<h4>Background</h4>Severe acute respiratory illness (SARI) is an important cause of mortality in young children, especially in children living with HIV infection. Disparities in SARI death in children aged <5 years exist in urban and rural areas.<h4>Objective</h4>To compare the factors associated with in-hospital death among children aged <5 years hospitalized with SARI in an urban vs. a rural setting in South Africa from 2009-2013.<h4>Methods</h4>Data were collected from hospitalized children with SARI in one urban and two rural sentinel surveillance hospitals. Nasopharyngeal aspirates were tested for ten respiratory viruses and blood for pneumococcal DNA using polymerase chain reaction. We used multivariable logistic regression to identify patient and clinical characteristics associated with in-hospital death.<h4>Results</h4>From 2009 through 2013, 5,297 children aged <5 years with SARI-associated hospital admission were enrolled; 3,811 (72%) in the urban and 1,486 (28%) in the rural hospitals. In-hospital case-fatality proportion (CFP) was higher in the rural hospitals (6.9%) than the urban hospital (1.3%, p<0.001), and among HIV-infected than the HIV-uninfected children (9.6% vs. 1.6%, p<0.001). In the urban hospital, HIV infection (odds ratio (OR):11.4, 95% confidence interval (CI):5.4-24.1) and presence of any other underlying illness (OR: 3.0, 95% CI: 1.0-9.2) were the only factors independently associated with death. In the rural hospitals, HIV infection (OR: 4.1, 95% CI: 2.3-7.1) and age <1 year (OR: 3.7, 95% CI: 1.9-7.2) were independently associated with death, whereas duration of hospitalization ≥5 days (OR: 0.5, 95% CI: 0.3-0.8) and any respiratory virus detection (OR: 0.4, 95% CI: 0.3-0.8) were negatively associated with death.<h4>Conclusion</h4>We found that the case-fatality proportion was substantially higher among children admitted to rural hospitals and HIV infected children with SARI in South Africa. While efforts to prevent and treat HIV infections in children may reduce SARI deaths, further efforts to address health care inequality in rural populations are needed.Oluwatosin A AyeniSibongile WalazaStefano TempiaMichelle GroomeKathleen KahnShabir A MadhiAdam L CohenJocelyn MoyesMarietjie VenterMarthi PretoriusFlorette TreurnichtOrienka HellfersceeAnne von GottbergNicole WolterCheryl CohenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255941 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Oluwatosin A Ayeni
Sibongile Walaza
Stefano Tempia
Michelle Groome
Kathleen Kahn
Shabir A Madhi
Adam L Cohen
Jocelyn Moyes
Marietjie Venter
Marthi Pretorius
Florette Treurnicht
Orienka Hellferscee
Anne von Gottberg
Nicole Wolter
Cheryl Cohen
Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.
description <h4>Background</h4>Severe acute respiratory illness (SARI) is an important cause of mortality in young children, especially in children living with HIV infection. Disparities in SARI death in children aged <5 years exist in urban and rural areas.<h4>Objective</h4>To compare the factors associated with in-hospital death among children aged <5 years hospitalized with SARI in an urban vs. a rural setting in South Africa from 2009-2013.<h4>Methods</h4>Data were collected from hospitalized children with SARI in one urban and two rural sentinel surveillance hospitals. Nasopharyngeal aspirates were tested for ten respiratory viruses and blood for pneumococcal DNA using polymerase chain reaction. We used multivariable logistic regression to identify patient and clinical characteristics associated with in-hospital death.<h4>Results</h4>From 2009 through 2013, 5,297 children aged <5 years with SARI-associated hospital admission were enrolled; 3,811 (72%) in the urban and 1,486 (28%) in the rural hospitals. In-hospital case-fatality proportion (CFP) was higher in the rural hospitals (6.9%) than the urban hospital (1.3%, p<0.001), and among HIV-infected than the HIV-uninfected children (9.6% vs. 1.6%, p<0.001). In the urban hospital, HIV infection (odds ratio (OR):11.4, 95% confidence interval (CI):5.4-24.1) and presence of any other underlying illness (OR: 3.0, 95% CI: 1.0-9.2) were the only factors independently associated with death. In the rural hospitals, HIV infection (OR: 4.1, 95% CI: 2.3-7.1) and age <1 year (OR: 3.7, 95% CI: 1.9-7.2) were independently associated with death, whereas duration of hospitalization ≥5 days (OR: 0.5, 95% CI: 0.3-0.8) and any respiratory virus detection (OR: 0.4, 95% CI: 0.3-0.8) were negatively associated with death.<h4>Conclusion</h4>We found that the case-fatality proportion was substantially higher among children admitted to rural hospitals and HIV infected children with SARI in South Africa. While efforts to prevent and treat HIV infections in children may reduce SARI deaths, further efforts to address health care inequality in rural populations are needed.
format article
author Oluwatosin A Ayeni
Sibongile Walaza
Stefano Tempia
Michelle Groome
Kathleen Kahn
Shabir A Madhi
Adam L Cohen
Jocelyn Moyes
Marietjie Venter
Marthi Pretorius
Florette Treurnicht
Orienka Hellferscee
Anne von Gottberg
Nicole Wolter
Cheryl Cohen
author_facet Oluwatosin A Ayeni
Sibongile Walaza
Stefano Tempia
Michelle Groome
Kathleen Kahn
Shabir A Madhi
Adam L Cohen
Jocelyn Moyes
Marietjie Venter
Marthi Pretorius
Florette Treurnicht
Orienka Hellferscee
Anne von Gottberg
Nicole Wolter
Cheryl Cohen
author_sort Oluwatosin A Ayeni
title Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.
title_short Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.
title_full Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.
title_fullStr Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.
title_full_unstemmed Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013.
title_sort mortality in children aged <5 years with severe acute respiratory illness in a high hiv-prevalence urban and rural areas of south africa, 2009-2013.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/f7c43c6a80194567beb9a9fdcabd7b8f
work_keys_str_mv AT oluwatosinaayeni mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT sibongilewalaza mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT stefanotempia mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT michellegroome mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT kathleenkahn mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT shabiramadhi mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT adamlcohen mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT jocelynmoyes mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT marietjieventer mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT marthipretorius mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT florettetreurnicht mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT orienkahellferscee mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT annevongottberg mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT nicolewolter mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
AT cherylcohen mortalityinchildrenaged5yearswithsevereacuterespiratoryillnessinahighhivprevalenceurbanandruralareasofsouthafrica20092013
_version_ 1718374322902401024