Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.

Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of th...

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Autores principales:	N S Kron, L A Fieber
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7c4d0d0bb6348debbbc8cf010f5186b
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spelling	oai:doaj.org-article:f7c4d0d0bb6348debbbc8cf010f5186b2021-12-02T20:07:08ZCo-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.1932-620310.1371/journal.pone.0252647https://doaj.org/article/f7c4d0d0bb6348debbbc8cf010f5186b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252647https://doaj.org/toc/1932-6203Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of the methodology often obscure larger expression patterns. Co-expression analysis offers a robust alternative that allows for identification of networks of genes and their putative central regulators. In an effort to expand upon previous work exploring neural aging in the marine model Aplysia californica, we used weighted gene correlation network analysis to identify co-expression networks in a targeted set of aging sensory neurons in these animals. We identified twelve modules, six of which were strongly positively or negatively associated with aging. Kyoto Encyclopedia of Genes analysis and investigation of central module transcripts identified signatures of metabolic impairment, increased reactive oxygen species, compromised proteostasis, disrupted signaling, and increased inflammation. Although modules with immune character were identified, there was no correlation between genes in Aplysia that increased in expression with aging and the orthologous genes in oyster displaying long-term increases in expression after a virus-like challenge. This suggests anti-viral response is not a driver of Aplysia sensory neuron aging.N S KronL A FieberPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252647 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q N S Kron L A Fieber Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.
description	Aging of the nervous system is typified by depressed metabolism, compromised proteostasis, and increased inflammation that results in cognitive impairment. Differential expression analysis is a popular technique for exploring the molecular underpinnings of neural aging, but technical drawbacks of the methodology often obscure larger expression patterns. Co-expression analysis offers a robust alternative that allows for identification of networks of genes and their putative central regulators. In an effort to expand upon previous work exploring neural aging in the marine model Aplysia californica, we used weighted gene correlation network analysis to identify co-expression networks in a targeted set of aging sensory neurons in these animals. We identified twelve modules, six of which were strongly positively or negatively associated with aging. Kyoto Encyclopedia of Genes analysis and investigation of central module transcripts identified signatures of metabolic impairment, increased reactive oxygen species, compromised proteostasis, disrupted signaling, and increased inflammation. Although modules with immune character were identified, there was no correlation between genes in Aplysia that increased in expression with aging and the orthologous genes in oyster displaying long-term increases in expression after a virus-like challenge. This suggests anti-viral response is not a driver of Aplysia sensory neuron aging.
format	article
author	N S Kron L A Fieber
author_facet	N S Kron L A Fieber
author_sort	N S Kron
title	Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.
title_short	Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.
title_full	Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.
title_fullStr	Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.
title_full_unstemmed	Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.
title_sort	co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in aplysia californica.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f7c4d0d0bb6348debbbc8cf010f5186b
work_keys_str_mv	AT nskron coexpressionanalysisidentifiesneuroinflammationasadriverofsensoryneuronaginginaplysiacalifornica AT lafieber coexpressionanalysisidentifiesneuroinflammationasadriverofsensoryneuronaginginaplysiacalifornica
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Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica.

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