Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study

Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study

Abstract This population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia in Japanese adults living in Chikusei city. Of 7109 participants with available d...

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Autores principales: Naohiko Aketa, Miki Uchino, Motoko Kawashima, Yuichi Uchino, Kenya Yuki, Yoko Ozawa, Mariko Sasaki, Kazumasa Yamagishi, Norie Sawada, Shoichiro Tsugane, Kazuo Tsubota, Hiroyasu Iso
Formato: article
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f7c7a59184084c689225622db18eecfe
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spelling oai:doaj.org-article:f7c7a59184084c689225622db18eecfe2021-12-02T17:05:00ZMyopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study10.1038/s41598-021-85617-42045-2322https://doaj.org/article/f7c7a59184084c689225622db18eecfe2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85617-4https://doaj.org/toc/2045-2322Abstract This population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia in Japanese adults living in Chikusei city. Of 7109 participants with available data, 5713 (2331 male and 3382 female) participants were eligible for analysis. After assessing the relationship between participant characteristics and spherical equivalent refraction (SER), the association of SER with the abnormal value of ECD (< 2000 cells/mm), CV (≥ 0.40), and HEX (≤ 50%) were determined using the logistic regression models adjusting for potential confounders (age, intraocular pressure, keratometric power, height, and antihypertensive drug use). In male participants, there was no statistically significant relationships between SER and endothelial parameters. In female participants, compared to emmetropia, SER ≤ − 6 D had significantly higher odds ratio (OR) of having the abnormal value of CV (OR = 2.07, 95% confidence interval [CI] 1.39–3.10) and HEX (OR = 2.04, 95% CI 1.29–3.23), adjusted for potential confounders, indicating that the high myopia was associated with the abnormal values of CV and HEX. Further adjustment for contact lenses wear partly attenuated these associations. Association between the SER and ECD was not detected.Naohiko AketaMiki UchinoMotoko KawashimaYuichi UchinoKenya YukiYoko OzawaMariko SasakiKazumasa YamagishiNorie SawadaShoichiro TsuganeKazuo TsubotaHiroyasu IsoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Naohiko Aketa
Miki Uchino
Motoko Kawashima
Yuichi Uchino
Kenya Yuki
Yoko Ozawa
Mariko Sasaki
Kazumasa Yamagishi
Norie Sawada
Shoichiro Tsugane
Kazuo Tsubota
Hiroyasu Iso
Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study
description Abstract This population-based cross-sectional study was performed to determine the mean corneal endothelial cell density (ECD), coefficient of variation (CV), and hexagonality (HEX), and their associations with myopia in Japanese adults living in Chikusei city. Of 7109 participants with available data, 5713 (2331 male and 3382 female) participants were eligible for analysis. After assessing the relationship between participant characteristics and spherical equivalent refraction (SER), the association of SER with the abnormal value of ECD (< 2000 cells/mm), CV (≥ 0.40), and HEX (≤ 50%) were determined using the logistic regression models adjusting for potential confounders (age, intraocular pressure, keratometric power, height, and antihypertensive drug use). In male participants, there was no statistically significant relationships between SER and endothelial parameters. In female participants, compared to emmetropia, SER ≤ − 6 D had significantly higher odds ratio (OR) of having the abnormal value of CV (OR = 2.07, 95% confidence interval [CI] 1.39–3.10) and HEX (OR = 2.04, 95% CI 1.29–3.23), adjusted for potential confounders, indicating that the high myopia was associated with the abnormal values of CV and HEX. Further adjustment for contact lenses wear partly attenuated these associations. Association between the SER and ECD was not detected.
format article
author Naohiko Aketa
Miki Uchino
Motoko Kawashima
Yuichi Uchino
Kenya Yuki
Yoko Ozawa
Mariko Sasaki
Kazumasa Yamagishi
Norie Sawada
Shoichiro Tsugane
Kazuo Tsubota
Hiroyasu Iso
author_facet Naohiko Aketa
Miki Uchino
Motoko Kawashima
Yuichi Uchino
Kenya Yuki
Yoko Ozawa
Mariko Sasaki
Kazumasa Yamagishi
Norie Sawada
Shoichiro Tsugane
Kazuo Tsubota
Hiroyasu Iso
author_sort Naohiko Aketa
title Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study
title_short Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study
title_full Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study
title_fullStr Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study
title_full_unstemmed Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study
title_sort myopia, corneal endothelial cell density and morphology in a japanese population-based cross-sectional study: the jphc-next eye study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f7c7a59184084c689225622db18eecfe
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