Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics

Recombinant T-cells receptors can redirect naïve T cells but often have low or uneven expression. Here, the authors model mutations in TCR constant domains to increase T cell receptor expression, assembly, and stability and generate bispecific molecules.

Guardado en:

Detalles Bibliográficos
Autores principales:	Karen Froning, Jack Maguire, Arlene Sereno, Flora Huang, Shawn Chang, Kenneth Weichert, Anton J. Frommelt, Jessica Dong, Xiufeng Wu, Heather Austin, Elaine M. Conner, Jonathan R. Fitchett, Aik Roy Heng, Deepa Balasubramaniam, Mark T. Hilgers, Brian Kuhlman, Stephen J. Demarest
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7c7bcb62ff841d9828b8f1c2709f751
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7c7bcb62ff841d9828b8f1c2709f751
record_format	dspace
spelling	oai:doaj.org-article:f7c7bcb62ff841d9828b8f1c2709f7512021-12-02T16:57:12ZComputational stabilization of T cell receptors allows pairing with antibodies to form bispecifics10.1038/s41467-020-16231-72041-1723https://doaj.org/article/f7c7bcb62ff841d9828b8f1c2709f7512020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16231-7https://doaj.org/toc/2041-1723Recombinant T-cells receptors can redirect naïve T cells but often have low or uneven expression. Here, the authors model mutations in TCR constant domains to increase T cell receptor expression, assembly, and stability and generate bispecific molecules.Karen FroningJack MaguireArlene SerenoFlora HuangShawn ChangKenneth WeichertAnton J. FrommeltJessica DongXiufeng WuHeather AustinElaine M. ConnerJonathan R. FitchettAik Roy HengDeepa BalasubramaniamMark T. HilgersBrian KuhlmanStephen J. DemarestNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karen Froning Jack Maguire Arlene Sereno Flora Huang Shawn Chang Kenneth Weichert Anton J. Frommelt Jessica Dong Xiufeng Wu Heather Austin Elaine M. Conner Jonathan R. Fitchett Aik Roy Heng Deepa Balasubramaniam Mark T. Hilgers Brian Kuhlman Stephen J. Demarest Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
description	Recombinant T-cells receptors can redirect naïve T cells but often have low or uneven expression. Here, the authors model mutations in TCR constant domains to increase T cell receptor expression, assembly, and stability and generate bispecific molecules.
format	article
author	Karen Froning Jack Maguire Arlene Sereno Flora Huang Shawn Chang Kenneth Weichert Anton J. Frommelt Jessica Dong Xiufeng Wu Heather Austin Elaine M. Conner Jonathan R. Fitchett Aik Roy Heng Deepa Balasubramaniam Mark T. Hilgers Brian Kuhlman Stephen J. Demarest
author_facet	Karen Froning Jack Maguire Arlene Sereno Flora Huang Shawn Chang Kenneth Weichert Anton J. Frommelt Jessica Dong Xiufeng Wu Heather Austin Elaine M. Conner Jonathan R. Fitchett Aik Roy Heng Deepa Balasubramaniam Mark T. Hilgers Brian Kuhlman Stephen J. Demarest
author_sort	Karen Froning
title	Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
title_short	Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
title_full	Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
title_fullStr	Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
title_full_unstemmed	Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics
title_sort	computational stabilization of t cell receptors allows pairing with antibodies to form bispecifics
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f7c7bcb62ff841d9828b8f1c2709f751
work_keys_str_mv	AT karenfroning computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT jackmaguire computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT arlenesereno computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT florahuang computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT shawnchang computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT kennethweichert computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT antonjfrommelt computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT jessicadong computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT xiufengwu computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT heatheraustin computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT elainemconner computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT jonathanrfitchett computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT aikroyheng computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT deepabalasubramaniam computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT markthilgers computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT briankuhlman computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics AT stephenjdemarest computationalstabilizationoftcellreceptorsallowspairingwithantibodiestoformbispecifics
_version_	1718382600189378560

Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics

Ejemplares similares