Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer

Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresse...

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Autores principales: Svitlana Tyekucheva, Michaela Bowden, Clyde Bango, Francesca Giunchi, Ying Huang, Chensheng Zhou, Arrigo Bondi, Rosina Lis, Mieke Van Hemelrijck, Ove Andrén, Sven-Olof Andersson, R. William Watson, Stephen Pennington, Stephen P. Finn, Neil E. Martin, Meir J. Stampfer, Giovanni Parmigiani, Kathryn L. Penney, Michelangelo Fiorentino, Lorelei A. Mucci, Massimo Loda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/f7c7f334fc234cc396a3e044b2046d32
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spelling oai:doaj.org-article:f7c7f334fc234cc396a3e044b2046d322021-12-02T14:40:47ZStromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer10.1038/s41467-017-00460-42041-1723https://doaj.org/article/f7c7f334fc234cc396a3e044b2046d322017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00460-4https://doaj.org/toc/2041-1723Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.Svitlana TyekuchevaMichaela BowdenClyde BangoFrancesca GiunchiYing HuangChensheng ZhouArrigo BondiRosina LisMieke Van HemelrijckOve AndrénSven-Olof AnderssonR. William WatsonStephen PenningtonStephen P. FinnNeil E. MartinMeir J. StampferGiovanni ParmigianiKathryn L. PenneyMichelangelo FiorentinoLorelei A. MucciMassimo LodaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Svitlana Tyekucheva
Michaela Bowden
Clyde Bango
Francesca Giunchi
Ying Huang
Chensheng Zhou
Arrigo Bondi
Rosina Lis
Mieke Van Hemelrijck
Ove Andrén
Sven-Olof Andersson
R. William Watson
Stephen Pennington
Stephen P. Finn
Neil E. Martin
Meir J. Stampfer
Giovanni Parmigiani
Kathryn L. Penney
Michelangelo Fiorentino
Lorelei A. Mucci
Massimo Loda
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
description Stromal cells contribute to tumor development but the mechanisms regulating this process are still unclear. Here the authors analyze gene expression profiles in the prostate and show that stromal gene signature changes ahead of the epithelial gene signature as prostate cancer initiates and progresses.
format article
author Svitlana Tyekucheva
Michaela Bowden
Clyde Bango
Francesca Giunchi
Ying Huang
Chensheng Zhou
Arrigo Bondi
Rosina Lis
Mieke Van Hemelrijck
Ove Andrén
Sven-Olof Andersson
R. William Watson
Stephen Pennington
Stephen P. Finn
Neil E. Martin
Meir J. Stampfer
Giovanni Parmigiani
Kathryn L. Penney
Michelangelo Fiorentino
Lorelei A. Mucci
Massimo Loda
author_facet Svitlana Tyekucheva
Michaela Bowden
Clyde Bango
Francesca Giunchi
Ying Huang
Chensheng Zhou
Arrigo Bondi
Rosina Lis
Mieke Van Hemelrijck
Ove Andrén
Sven-Olof Andersson
R. William Watson
Stephen Pennington
Stephen P. Finn
Neil E. Martin
Meir J. Stampfer
Giovanni Parmigiani
Kathryn L. Penney
Michelangelo Fiorentino
Lorelei A. Mucci
Massimo Loda
author_sort Svitlana Tyekucheva
title Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_short Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_full Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_fullStr Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_full_unstemmed Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
title_sort stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/f7c7f334fc234cc396a3e044b2046d32
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