Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus

Jiangman Liu, Guangping Lang, Jingshan Shi Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of ChinaCorrespondence: Jingshan Shi Te...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liu J, Lang G, Shi J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	type 2 diabetes mellitus β-cells pdx-1 epigenetic dna methylation Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f7c9530015af497eaedf0fda607066fb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7c9530015af497eaedf0fda607066fb
record_format	dspace
spelling	oai:doaj.org-article:f7c9530015af497eaedf0fda607066fb2021-12-02T14:24:11ZEpigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/f7c9530015af497eaedf0fda607066fb2021-02-01T00:00:00Zhttps://www.dovepress.com/epigenetic-regulation-of-pdx-1-in-type-2-diabetes-mellitus-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jiangman Liu, Guangping Lang, Jingshan Shi Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of ChinaCorrespondence: Jingshan Shi Tel +86-851-286-436-66Fax +86-851-286-423-03Email shijs@zmu.edu.cnAbstract: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia which is caused by insufficient insulin secretion or insulin resistance. Interaction of genetic, epigenetic and environmental factors plays a significant role in the development of T2DM. Several environmental factors including diet and lifestyle, as well as age have been associated with an increased risk for T2DM. It has been demonstrated that these environmental factors may affect global epigenetic status, and alter the expression of susceptible genes, thereby contributing to the pathogenesis of T2DM. In recent years, a growing body of molecular and genetic studies in diabetes have been focused on the ways to restore the numbers or function of β-cells in order to reverse a range of metabolic consequences of insulin deficiency. The pancreatic duodenal homeobox 1 (PDX-1) is a transcriptional factor that is essential for the development and function of islet cells. A number of studies have shown that there is a significant increase in the level of DNA methylation of PDX-1 resulting in reduced activity in T2DM islets. The decrease in PDX-1 activity may be a critical mediator causing dysregulation of pancreatic β cells in T2DM. This article reviews the epigenetic mechanisms of PDX-1 involved in T2DM, focusing on diabetes and DNA methylation, and discusses some potential strategies for the application of PDX-1 in the treatment of diabetes.Keywords: type 2 diabetes mellitus, β-cells, PDX-1, epigenetic, DNA methylationLiu JLang GShi JDove Medical Pressarticletype 2 diabetes mellitusβ-cellspdx-1epigeneticdna methylationSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 431-442 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus β-cells pdx-1 epigenetic dna methylation Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes mellitus β-cells pdx-1 epigenetic dna methylation Specialties of internal medicine RC581-951 Liu J Lang G Shi J Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
description	Jiangman Liu, Guangping Lang, Jingshan Shi Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, People’s Republic of ChinaCorrespondence: Jingshan Shi Tel +86-851-286-436-66Fax +86-851-286-423-03Email shijs@zmu.edu.cnAbstract: Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia which is caused by insufficient insulin secretion or insulin resistance. Interaction of genetic, epigenetic and environmental factors plays a significant role in the development of T2DM. Several environmental factors including diet and lifestyle, as well as age have been associated with an increased risk for T2DM. It has been demonstrated that these environmental factors may affect global epigenetic status, and alter the expression of susceptible genes, thereby contributing to the pathogenesis of T2DM. In recent years, a growing body of molecular and genetic studies in diabetes have been focused on the ways to restore the numbers or function of β-cells in order to reverse a range of metabolic consequences of insulin deficiency. The pancreatic duodenal homeobox 1 (PDX-1) is a transcriptional factor that is essential for the development and function of islet cells. A number of studies have shown that there is a significant increase in the level of DNA methylation of PDX-1 resulting in reduced activity in T2DM islets. The decrease in PDX-1 activity may be a critical mediator causing dysregulation of pancreatic β cells in T2DM. This article reviews the epigenetic mechanisms of PDX-1 involved in T2DM, focusing on diabetes and DNA methylation, and discusses some potential strategies for the application of PDX-1 in the treatment of diabetes.Keywords: type 2 diabetes mellitus, β-cells, PDX-1, epigenetic, DNA methylation
format	article
author	Liu J Lang G Shi J
author_facet	Liu J Lang G Shi J
author_sort	Liu J
title	Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
title_short	Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
title_full	Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
title_fullStr	Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
title_full_unstemmed	Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus
title_sort	epigenetic regulation of pdx-1 in type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f7c9530015af497eaedf0fda607066fb
work_keys_str_mv	AT liuj epigeneticregulationofpdx1intype2diabetesmellitus AT langg epigeneticregulationofpdx1intype2diabetesmellitus AT shij epigeneticregulationofpdx1intype2diabetesmellitus
_version_	1718391463981613056

Epigenetic Regulation of PDX-1 in Type 2 Diabetes Mellitus

Ejemplares similares