Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important immunomodulatory activities and exert influence on a wide variety of immune cells, such as B cells, eosinophil...

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Autores principales:	Milena Iwaszko, Sylwia Biały, Katarzyna Bogunia-Kubik
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammatory arthritis rheumatoid arthritis psoriatic arthritis ankylosing spondylitis spondyloarthritis IL-4 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f7c96085f4b24883a7582911cb09fe8b
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spelling	oai:doaj.org-article:f7c96085f4b24883a7582911cb09fe8b2021-11-25T17:10:16ZSignificance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis10.3390/cells101130002073-4409https://doaj.org/article/f7c96085f4b24883a7582911cb09fe8b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3000https://doaj.org/toc/2073-4409Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important immunomodulatory activities and exert influence on a wide variety of immune cells, such as B cells, eosinophils, basophils, monocytes, fibroblasts, endothelial cells, airway epithelial cells, smooth muscle cells, and keratinocytes. Recent studies have implicated IL-4 and IL-13 in the development of various autoimmune diseases. Additionally, these cytokines have emerged as potential players in pathogenesis of inflammatory arthritis. Recent findings suggest that the IL-4 and IL-13 might play a significant role in the downregulation of inflammatory processes underlying RA pathology, and beneficially modulate the course of the disease. This review summarizes the biological features of the IL-4 and IL-13 and provides current knowledge regarding the role of these cytokines in inflammatory arthritis.Milena IwaszkoSylwia BiałyKatarzyna Bogunia-KubikMDPI AGarticleinflammatory arthritisrheumatoid arthritispsoriatic arthritisankylosing spondylitisspondyloarthritisIL-4Biology (General)QH301-705.5ENCells, Vol 10, Iss 3000, p 3000 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory arthritis rheumatoid arthritis psoriatic arthritis ankylosing spondylitis spondyloarthritis IL-4 Biology (General) QH301-705.5
spellingShingle	inflammatory arthritis rheumatoid arthritis psoriatic arthritis ankylosing spondylitis spondyloarthritis IL-4 Biology (General) QH301-705.5 Milena Iwaszko Sylwia Biały Katarzyna Bogunia-Kubik Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
description	Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important immunomodulatory activities and exert influence on a wide variety of immune cells, such as B cells, eosinophils, basophils, monocytes, fibroblasts, endothelial cells, airway epithelial cells, smooth muscle cells, and keratinocytes. Recent studies have implicated IL-4 and IL-13 in the development of various autoimmune diseases. Additionally, these cytokines have emerged as potential players in pathogenesis of inflammatory arthritis. Recent findings suggest that the IL-4 and IL-13 might play a significant role in the downregulation of inflammatory processes underlying RA pathology, and beneficially modulate the course of the disease. This review summarizes the biological features of the IL-4 and IL-13 and provides current knowledge regarding the role of these cytokines in inflammatory arthritis.
format	article
author	Milena Iwaszko Sylwia Biały Katarzyna Bogunia-Kubik
author_facet	Milena Iwaszko Sylwia Biały Katarzyna Bogunia-Kubik
author_sort	Milena Iwaszko
title	Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
title_short	Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
title_full	Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
title_fullStr	Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
title_full_unstemmed	Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis
title_sort	significance of interleukin (il)-4 and il-13 in inflammatory arthritis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f7c96085f4b24883a7582911cb09fe8b
work_keys_str_mv	AT milenaiwaszko significanceofinterleukinil4andil13ininflammatoryarthritis AT sylwiabiały significanceofinterleukinil4andil13ininflammatoryarthritis AT katarzynaboguniakubik significanceofinterleukinil4andil13ininflammatoryarthritis
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Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

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