Structure of general-population antibody titer distributions to influenza A virus

Abstract Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantit...

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Autores principales:	Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E. Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P. Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F. Boni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7c9dd1a6c6f4cf0958a60c80e752a36
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spelling	oai:doaj.org-article:f7c9dd1a6c6f4cf0958a60c80e752a362021-12-02T16:06:04ZStructure of general-population antibody titer distributions to influenza A virus10.1038/s41598-017-06177-02045-2322https://doaj.org/article/f7c9dd1a6c6f4cf0958a60c80e752a362017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06177-0https://doaj.org/toc/2045-2322Abstract Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population’s natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states – naiveté, recent infection, non-recent infection, childhood infection – depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.Nguyen Thi Duy NhatStacy ToddErwin de BruinTran Thi Nhu ThaoNguyen Ha Thao VyTran Minh QuanDao Nguyen VinhJanko van BeekPham Hong AnhHa Minh LamNguyen Thanh HungNguyen Thi Le ThanhHuynh Le Anh HuyVo Thi Hong HaStephen BakerGuy E. ThwaitesNguyen Thi Nam LienTran Thi Kim HongJeremy FarrarCameron P. SimmonsNguyen Van Vinh ChauMarion KoopmansMaciej F. BoniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nguyen Thi Duy Nhat Stacy Todd Erwin de Bruin Tran Thi Nhu Thao Nguyen Ha Thao Vy Tran Minh Quan Dao Nguyen Vinh Janko van Beek Pham Hong Anh Ha Minh Lam Nguyen Thanh Hung Nguyen Thi Le Thanh Huynh Le Anh Huy Vo Thi Hong Ha Stephen Baker Guy E. Thwaites Nguyen Thi Nam Lien Tran Thi Kim Hong Jeremy Farrar Cameron P. Simmons Nguyen Van Vinh Chau Marion Koopmans Maciej F. Boni Structure of general-population antibody titer distributions to influenza A virus
description	Abstract Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific antibody, despite the fact that many assays measure continuous quantities. A population’s natural distribution of antibody titers to an endemic infectious disease may include information on multiple serological states – naiveté, recent infection, non-recent infection, childhood infection – depending on the disease in question and the acquisition and waning patterns of immunity. In this study, we investigate 20,152 general-population serum samples from southern Vietnam collected between 2009 and 2013 from which we report antibody titers to the influenza virus HA1 protein using a continuous titer measurement from a protein microarray assay. We describe the distributions of antibody titers to subtypes 2009 H1N1 and H3N2. Using a model selection approach to fit mixture distributions, we show that 2009 H1N1 antibody titers fall into four titer subgroups and that H3N2 titers fall into three subgroups. For H1N1, our interpretation is that the two highest-titer subgroups correspond to recent and historical infection, which is consistent with 2009 pandemic attack rates. Similar interpretations are available for H3N2, but right-censoring of titers makes these interpretations difficult to validate.
format	article
author	Nguyen Thi Duy Nhat Stacy Todd Erwin de Bruin Tran Thi Nhu Thao Nguyen Ha Thao Vy Tran Minh Quan Dao Nguyen Vinh Janko van Beek Pham Hong Anh Ha Minh Lam Nguyen Thanh Hung Nguyen Thi Le Thanh Huynh Le Anh Huy Vo Thi Hong Ha Stephen Baker Guy E. Thwaites Nguyen Thi Nam Lien Tran Thi Kim Hong Jeremy Farrar Cameron P. Simmons Nguyen Van Vinh Chau Marion Koopmans Maciej F. Boni
author_facet	Nguyen Thi Duy Nhat Stacy Todd Erwin de Bruin Tran Thi Nhu Thao Nguyen Ha Thao Vy Tran Minh Quan Dao Nguyen Vinh Janko van Beek Pham Hong Anh Ha Minh Lam Nguyen Thanh Hung Nguyen Thi Le Thanh Huynh Le Anh Huy Vo Thi Hong Ha Stephen Baker Guy E. Thwaites Nguyen Thi Nam Lien Tran Thi Kim Hong Jeremy Farrar Cameron P. Simmons Nguyen Van Vinh Chau Marion Koopmans Maciej F. Boni
author_sort	Nguyen Thi Duy Nhat
title	Structure of general-population antibody titer distributions to influenza A virus
title_short	Structure of general-population antibody titer distributions to influenza A virus
title_full	Structure of general-population antibody titer distributions to influenza A virus
title_fullStr	Structure of general-population antibody titer distributions to influenza A virus
title_full_unstemmed	Structure of general-population antibody titer distributions to influenza A virus
title_sort	structure of general-population antibody titer distributions to influenza a virus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7c9dd1a6c6f4cf0958a60c80e752a36
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Structure of general-population antibody titer distributions to influenza A virus

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