Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation

Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation

Ultraconserved RNAs are a class of long non-coding RNAs whose functions are yet to be identified. Here Guo and colleagues show that an ultraconserved RNA uc.372 promotes lipogenesis and lipid accumulation within the hepatocytes by suppressing the maturation of miR-195/miR-4668 that inhibits lipogeni...

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Autores principales: Jun Guo, Weiwei Fang, Libo Sun, Yonggang Lu, Lin Dou, Xiuqing Huang, Weiqing Tang, Liqing Yu, Jian Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/f7ca35753a8e4489875426859f45a85a
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spelling oai:doaj.org-article:f7ca35753a8e4489875426859f45a85a2021-12-02T16:49:18ZUltraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation10.1038/s41467-018-03072-82041-1723https://doaj.org/article/f7ca35753a8e4489875426859f45a85a2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03072-8https://doaj.org/toc/2041-1723Ultraconserved RNAs are a class of long non-coding RNAs whose functions are yet to be identified. Here Guo and colleagues show that an ultraconserved RNA uc.372 promotes lipogenesis and lipid accumulation within the hepatocytes by suppressing the maturation of miR-195/miR-4668 that inhibits lipogenic gene expression.Jun GuoWeiwei FangLibo SunYonggang LuLin DouXiuqing HuangWeiqing TangLiqing YuJian LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jun Guo
Weiwei Fang
Libo Sun
Yonggang Lu
Lin Dou
Xiuqing Huang
Weiqing Tang
Liqing Yu
Jian Li
Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
description Ultraconserved RNAs are a class of long non-coding RNAs whose functions are yet to be identified. Here Guo and colleagues show that an ultraconserved RNA uc.372 promotes lipogenesis and lipid accumulation within the hepatocytes by suppressing the maturation of miR-195/miR-4668 that inhibits lipogenic gene expression.
format article
author Jun Guo
Weiwei Fang
Libo Sun
Yonggang Lu
Lin Dou
Xiuqing Huang
Weiqing Tang
Liqing Yu
Jian Li
author_facet Jun Guo
Weiwei Fang
Libo Sun
Yonggang Lu
Lin Dou
Xiuqing Huang
Weiqing Tang
Liqing Yu
Jian Li
author_sort Jun Guo
title Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
title_short Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
title_full Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
title_fullStr Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
title_full_unstemmed Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
title_sort ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing mir-195/mir4668 maturation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f7ca35753a8e4489875426859f45a85a
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AT liqingyu ultraconservedelementuc372driveshepaticlipidaccumulationbysuppressingmir195mir4668maturation
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