Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

Abstract Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administrat...

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Autores principales:	Ann-Yae Na, Jung Jae Jo, Oh Kwang Kwon, Piljoung Cho, Yan Gao, Ju-Hyun Kim, Kyu Min Kim, Sung Hwan Ki, Sangkyu Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7ccb9735d094710b402bb4556062aa7
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spelling	oai:doaj.org-article:f7ccb9735d094710b402bb4556062aa72021-12-02T17:52:11ZCharacterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis10.1038/s41598-021-91664-82045-2322https://doaj.org/article/f7ccb9735d094710b402bb4556062aa72021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91664-8https://doaj.org/toc/2045-2322Abstract Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (H2S) synthesis in the liver. This investigation provides novel evidence that sub-chronic administration of KRG can elevate H2S production by increasing protein expression of CBS and CSE in the liver.Ann-Yae NaJung Jae JoOh Kwang KwonPiljoung ChoYan GaoJu-Hyun KimKyu Min KimSung Hwan KiSangkyu LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ann-Yae Na Jung Jae Jo Oh Kwang Kwon Piljoung Cho Yan Gao Ju-Hyun Kim Kyu Min Kim Sung Hwan Ki Sangkyu Lee Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
description	Abstract Ginseng (Panax ginseng Meyer) is commonly used as an herbal remedy worldwide. Few studies have explored the possible physiological changes in the liver although patients often self-medicate with ginseng preparations, which may lead to exceeding the recommended dose for long-term administration. Here, we analyzed changes in the hepatic proteins of mouse livers using quantitative proteomics after sub-chronic administration of Korean red ginseng (KRG) extract (control group and 0.5, 1.0, and 2.0 g/kg KRG) using tandem mass tag (TMT) 6‐plex technology. The 1.0 and 2.0 g/kg KRG groups exhibited signs of liver injury, including increased levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) in the serum. Furthermore, serum glucose levels were significantly higher following KRG administration compared with the control group. Based on the upregulated proteins found in the proteomic analysis, we found that increased cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) levels promoted greater hydrogen sulfide (H2S) synthesis in the liver. This investigation provides novel evidence that sub-chronic administration of KRG can elevate H2S production by increasing protein expression of CBS and CSE in the liver.
format	article
author	Ann-Yae Na Jung Jae Jo Oh Kwang Kwon Piljoung Cho Yan Gao Ju-Hyun Kim Kyu Min Kim Sung Hwan Ki Sangkyu Lee
author_facet	Ann-Yae Na Jung Jae Jo Oh Kwang Kwon Piljoung Cho Yan Gao Ju-Hyun Kim Kyu Min Kim Sung Hwan Ki Sangkyu Lee
author_sort	Ann-Yae Na
title	Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
title_short	Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
title_full	Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
title_fullStr	Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
title_full_unstemmed	Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
title_sort	characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7ccb9735d094710b402bb4556062aa7
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Characterization of hyperglycemia due to sub-chronic administration of red ginseng extract via comparative global proteomic analysis

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