Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol

Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase, and displays pronounced activity against patho...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yue Fu, David Estoppey, Silvio Roggo, Dominik Pistorius, Florian Fuchs, Christian Studer, Ashraf S. Ibrahim, Thomas Aust, Frederic Grandjean, Manuel Mihalic, Klaus Memmert, Vivian Prindle, Etienne Richard, Ralph Riedl, Sven Schuierer, Eric Weber, Jürg Hunziker, Frank Petersen, Jianshi Tao, Dominic Hoepfner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f7cd22501a204070a70510bf4ba6dfe2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f7cd22501a204070a70510bf4ba6dfe2
record_format dspace
spelling oai:doaj.org-article:f7cd22501a204070a70510bf4ba6dfe22021-12-02T18:34:08ZJawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol10.1038/s41467-020-17221-52041-1723https://doaj.org/article/f7cd22501a204070a70510bf4ba6dfe22020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17221-5https://doaj.org/toc/2041-1723Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase, and displays pronounced activity against pathogenic fungi of the order Mucorales.Yue FuDavid EstoppeySilvio RoggoDominik PistoriusFlorian FuchsChristian StuderAshraf S. IbrahimThomas AustFrederic GrandjeanManuel MihalicKlaus MemmertVivian PrindleEtienne RichardRalph RiedlSven SchuiererEric WeberJürg HunzikerFrank PetersenJianshi TaoDominic HoepfnerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yue Fu
David Estoppey
Silvio Roggo
Dominik Pistorius
Florian Fuchs
Christian Studer
Ashraf S. Ibrahim
Thomas Aust
Frederic Grandjean
Manuel Mihalic
Klaus Memmert
Vivian Prindle
Etienne Richard
Ralph Riedl
Sven Schuierer
Eric Weber
Jürg Hunziker
Frank Petersen
Jianshi Tao
Dominic Hoepfner
Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
description Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase, and displays pronounced activity against pathogenic fungi of the order Mucorales.
format article
author Yue Fu
David Estoppey
Silvio Roggo
Dominik Pistorius
Florian Fuchs
Christian Studer
Ashraf S. Ibrahim
Thomas Aust
Frederic Grandjean
Manuel Mihalic
Klaus Memmert
Vivian Prindle
Etienne Richard
Ralph Riedl
Sven Schuierer
Eric Weber
Jürg Hunziker
Frank Petersen
Jianshi Tao
Dominic Hoepfner
author_facet Yue Fu
David Estoppey
Silvio Roggo
Dominik Pistorius
Florian Fuchs
Christian Studer
Ashraf S. Ibrahim
Thomas Aust
Frederic Grandjean
Manuel Mihalic
Klaus Memmert
Vivian Prindle
Etienne Richard
Ralph Riedl
Sven Schuierer
Eric Weber
Jürg Hunziker
Frank Petersen
Jianshi Tao
Dominic Hoepfner
author_sort Yue Fu
title Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
title_short Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
title_full Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
title_fullStr Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
title_full_unstemmed Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
title_sort jawsamycin exhibits in vivo antifungal properties by inhibiting spt14/gpi3-mediated biosynthesis of glycosylphosphatidylinositol
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f7cd22501a204070a70510bf4ba6dfe2
work_keys_str_mv AT yuefu jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT davidestoppey jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT silvioroggo jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT dominikpistorius jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT florianfuchs jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT christianstuder jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT ashrafsibrahim jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT thomasaust jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT fredericgrandjean jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT manuelmihalic jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT klausmemmert jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT vivianprindle jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT etiennerichard jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT ralphriedl jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT svenschuierer jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT ericweber jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT jurghunziker jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT frankpetersen jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT jianshitao jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
AT dominichoepfner jawsamycinexhibitsinvivoantifungalpropertiesbyinhibitingspt14gpi3mediatedbiosynthesisofglycosylphosphatidylinositol
_version_ 1718377956480385024

Ejemplares similares