Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
Biosynthesis of glycosylphosphatidylinositol (GPI) is essential for the integrity of the fungal cell wall. Here, the authors show that the natural product jawsamycin inhibits GPI biosynthesis by targeting a subunit of the fungal UDP-glycosyltransferase, and displays pronounced activity against patho...
Guardado en:
Autores principales: | Yue Fu, David Estoppey, Silvio Roggo, Dominik Pistorius, Florian Fuchs, Christian Studer, Ashraf S. Ibrahim, Thomas Aust, Frederic Grandjean, Manuel Mihalic, Klaus Memmert, Vivian Prindle, Etienne Richard, Ralph Riedl, Sven Schuierer, Eric Weber, Jürg Hunziker, Frank Petersen, Jianshi Tao, Dominic Hoepfner |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/f7cd22501a204070a70510bf4ba6dfe2 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Author Correction: Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
por: Yue Fu, et al.
Publicado: (2020) -
Determinants of GPI-PLC localisation to the flagellum and access to GPI-anchored substrates in trypanosomes.
por: Jack Sunter, et al.
Publicado: (2013) -
Structural analysis of the GPI glycan.
por: Miyako Nakano, et al.
Publicado: (2021) -
A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins
por: Si-Si Liu, et al.
Publicado: (2021) -
Determination of the lipid composition of the GPI anchor.
por: Auxiliadora Aguilera-Romero, et al.
Publicado: (2021)