Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland

Aim. To evaluate the results of combined and integrated treatment in patients with locally advanced thyroid cancer. Material and Methods. From 2004 to 2018, we operated 1,693 patients with differentiated thyroid cancer; the incidence of locally advanced cancer of the thyroid gland was 5.2%. In t...

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Autores principales:	I.V. Deineko, E.V. Zhmurenko, V.А. Kravchenko, S.P. Merenkova
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2019
Materias:	local-distributed cancer of the thyroid gland, complex treatment, combined operations, thyroidectomy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7cde0598f3e41488edbd9a3b4f219f1
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spelling	oai:doaj.org-article:f7cde0598f3e41488edbd9a3b4f219f12021-11-10T19:49:51ZCombined and complex treatment of high-differential local-distributed cancer of the thyroid gland1029-42442415-330310.25040/aml2019.04.018https://doaj.org/article/f7cde0598f3e41488edbd9a3b4f219f12019-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/46https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To evaluate the results of combined and integrated treatment in patients with locally advanced thyroid cancer. Material and Methods. From 2004 to 2018, we operated 1,693 patients with differentiated thyroid cancer; the incidence of locally advanced cancer of the thyroid gland was 5.2%. In the case of tumours spreading beyond the thyroid gland, patients were subjected to fibro-laringotracheoscopy, fibro-esophagoscopy, spiral computer or magnetic resonance imaging (1.5 T) of the neck and upper mediastinum, dopplerography, and computer angiography of the neck arteries. Results and Discussion. The most commonly reported cases of tumor invasion were invasions into the upper airways (56 (63.6%) patients). Of all patients with locally advanced cancer, 25 (28.4%) had combined lesions of vital structures. All patients received surgical treatment depending on degree and nature of the spreading of the tumor process. Conclusions. Performing surgical interventions allows increasing the indicators of three-year survival to 83% and reduces the number of cases of recurrence of the disease to 21%. Execution of the trachea resection (up to 3 rings) allows instant removal and closure of the defect in case of the upper airways damage. However, when removing 3 or 4 rings, there is a need for projective tracheostomy to prevent the phenomena of insolvency of seams. Performing neoadjuvant polychemotherapy in a group of patients with highly differentiated cancers can achieve regression of the tumor and transform it into an operable one.I.V. DeinekoE.V. ZhmurenkoV.А. KravchenkoS.P. MerenkovaDanylo Halytsky Lviv National Medical Universityarticlelocal-distributed cancer of the thyroid gland, complex treatment, combined operations, thyroidectomyMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 25, Iss 4, Pp 18-22 (2019)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	local-distributed cancer of the thyroid gland, complex treatment, combined operations, thyroidectomy Medicine (General) R5-920
spellingShingle	local-distributed cancer of the thyroid gland, complex treatment, combined operations, thyroidectomy Medicine (General) R5-920 I.V. Deineko E.V. Zhmurenko V.А. Kravchenko S.P. Merenkova Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
description	Aim. To evaluate the results of combined and integrated treatment in patients with locally advanced thyroid cancer. Material and Methods. From 2004 to 2018, we operated 1,693 patients with differentiated thyroid cancer; the incidence of locally advanced cancer of the thyroid gland was 5.2%. In the case of tumours spreading beyond the thyroid gland, patients were subjected to fibro-laringotracheoscopy, fibro-esophagoscopy, spiral computer or magnetic resonance imaging (1.5 T) of the neck and upper mediastinum, dopplerography, and computer angiography of the neck arteries. Results and Discussion. The most commonly reported cases of tumor invasion were invasions into the upper airways (56 (63.6%) patients). Of all patients with locally advanced cancer, 25 (28.4%) had combined lesions of vital structures. All patients received surgical treatment depending on degree and nature of the spreading of the tumor process. Conclusions. Performing surgical interventions allows increasing the indicators of three-year survival to 83% and reduces the number of cases of recurrence of the disease to 21%. Execution of the trachea resection (up to 3 rings) allows instant removal and closure of the defect in case of the upper airways damage. However, when removing 3 or 4 rings, there is a need for projective tracheostomy to prevent the phenomena of insolvency of seams. Performing neoadjuvant polychemotherapy in a group of patients with highly differentiated cancers can achieve regression of the tumor and transform it into an operable one.
format	article
author	I.V. Deineko E.V. Zhmurenko V.А. Kravchenko S.P. Merenkova
author_facet	I.V. Deineko E.V. Zhmurenko V.А. Kravchenko S.P. Merenkova
author_sort	I.V. Deineko
title	Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
title_short	Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
title_full	Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
title_fullStr	Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
title_full_unstemmed	Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
title_sort	combined and complex treatment of high-differential local-distributed cancer of the thyroid gland
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2019
url	https://doaj.org/article/f7cde0598f3e41488edbd9a3b4f219f1
work_keys_str_mv	AT ivdeineko combinedandcomplextreatmentofhighdifferentiallocaldistributedcancerofthethyroidgland AT evzhmurenko combinedandcomplextreatmentofhighdifferentiallocaldistributedcancerofthethyroidgland AT vakravchenko combinedandcomplextreatmentofhighdifferentiallocaldistributedcancerofthethyroidgland AT spmerenkova combinedandcomplextreatmentofhighdifferentiallocaldistributedcancerofthethyroidgland
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Combined and complex treatment of high-differential local-distributed cancer of the thyroid gland

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