TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a reduced neuronal firing rate and a male-like su...

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Autores principales:	Chunmei Wang, Yanlin He, Pingwen Xu, Yongjie Yang, Kenji Saito, Yan Xia, Xiaofeng Yan, Antentor Hinton Jr, Chunling Yan, Hongfang Ding, Likai Yu, Gang Shu, Rajat Gupta, Qi Wu, Qingchun Tong, William R. Lagor, Elsa R. Flores, Yong Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7cdf5faab7a4548b6351ebcba1722a5
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spelling	oai:doaj.org-article:f7cdf5faab7a4548b6351ebcba1722a52021-12-02T17:32:45ZTAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis10.1038/s41467-018-03796-72041-1723https://doaj.org/article/f7cdf5faab7a4548b6351ebcba1722a52018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03796-7https://doaj.org/toc/2041-1723Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a reduced neuronal firing rate and a male-like susceptibility to diet-induced obesity.Chunmei WangYanlin HePingwen XuYongjie YangKenji SaitoYan XiaXiaofeng YanAntentor Hinton JrChunling YanHongfang DingLikai YuGang ShuRajat GuptaQi WuQingchun TongWilliam R. LagorElsa R. FloresYong XuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chunmei Wang Yanlin He Pingwen Xu Yongjie Yang Kenji Saito Yan Xia Xiaofeng Yan Antentor Hinton Jr Chunling Yan Hongfang Ding Likai Yu Gang Shu Rajat Gupta Qi Wu Qingchun Tong William R. Lagor Elsa R. Flores Yong Xu TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
description	Sexual dimorphism exists in a number of physiological processes, including energy homeostasis. Here, the authors show that pro-opiomelanocortin neurons in female mice fire more rapidly than males, and that deletion of the transcription TAp63 leads to a reduced neuronal firing rate and a male-like susceptibility to diet-induced obesity.
format	article
author	Chunmei Wang Yanlin He Pingwen Xu Yongjie Yang Kenji Saito Yan Xia Xiaofeng Yan Antentor Hinton Jr Chunling Yan Hongfang Ding Likai Yu Gang Shu Rajat Gupta Qi Wu Qingchun Tong William R. Lagor Elsa R. Flores Yong Xu
author_facet	Chunmei Wang Yanlin He Pingwen Xu Yongjie Yang Kenji Saito Yan Xia Xiaofeng Yan Antentor Hinton Jr Chunling Yan Hongfang Ding Likai Yu Gang Shu Rajat Gupta Qi Wu Qingchun Tong William R. Lagor Elsa R. Flores Yong Xu
author_sort	Chunmei Wang
title	TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_short	TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_full	TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_fullStr	TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_full_unstemmed	TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
title_sort	tap63 contributes to sexual dimorphism in pomc neuron functions and energy homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f7cdf5faab7a4548b6351ebcba1722a5
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TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

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