CD40L deficiency attenuates diet-induced adipose tissue inflammation by impairing immune cell accumulation and production of pathogenic IgG-antibodies.
<h4>Background</h4>Adipose tissue inflammation fuels the metabolic syndrome. We recently reported that CD40L--an established marker and mediator of cardiovascular disease--induces inflammatory cytokine production in adipose cells in vitro. Here, we tested the hypothesis that CD40L defici...
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Autores principales: | Dennis Wolf, Felix Jehle, Alexandra Ortiz Rodriguez, Bianca Dufner, Natalie Hoppe, Christian Colberg, Andrey Lozhkin, Nicole Bassler, Benjamin Rupprecht, Ansgar Wiedemann, Ingo Hilgendorf, Peter Stachon, Florian Willecke, Mark Febbraio, Constantin von zur Muhlen, Christoph J Binder, Christoph Bode, Andreas Zirlik, Karlheinz Peter |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/f7d4422239554d5396a325a3d1078fdd |
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