Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy

Abstract Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to the lung by targeting a recognition factor present on the surface of lung tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed on the surface of lung cancer cells with a restricted exp...

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Autores principales:	Congcong Lin, Blenda Chi Kwan Wong, Hubiao Chen, Zhaoxiang Bian, Ge Zhang, Xue Zhang, Muhammad Kashif Riaz, Deependra Tyagi, Ge Lin, Yanbo Zhang, Jinjin Wang, Aiping Lu, Zhijun Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7d4a030eccf4f6397379584c5f7a4bf
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spelling	oai:doaj.org-article:f7d4a030eccf4f6397379584c5f7a4bf2021-12-02T15:06:11ZPulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy10.1038/s41598-017-00957-42045-2322https://doaj.org/article/f7d4a030eccf4f6397379584c5f7a4bf2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00957-4https://doaj.org/toc/2045-2322Abstract Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to the lung by targeting a recognition factor present on the surface of lung tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed on the surface of lung cancer cells with a restricted expression in normal lungs. Here, we explored the utility of anti-carbonic anhydrase IX (CA IX) antibody, conjugated to the surface of triptolide (TPL)-loaded liposomes (CA IX-TPL-Lips), to promote the therapeutic effects for lung cancer via pulmonary administration. It was found that the CA IX-TPL-Lips significantly improved the cellular uptake efficiency in both CA IX-positive human non-small cell lung cancer cells (A549) and A549 tumor spheroids, resulting in the efficient cell killing compared with free TPL and non-targeted TPL-Lips. In vivo, CA IX-Lips via pulmonary delivery showed specificity and a sustained release property resided up to 96 h in the lung, both of which improved the efficiency of TPL formulations in restraining tumor growth and significantly prolonged the lifespan of mice with orthotopic lung tumors. The results suggest that CA IX-decorated liposomes can potentially be used as an effective therapeutic strategy for lung cancer.Congcong LinBlenda Chi Kwan WongHubiao ChenZhaoxiang BianGe ZhangXue ZhangMuhammad Kashif RiazDeependra TyagiGe LinYanbo ZhangJinjin WangAiping LuZhijun YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Congcong Lin Blenda Chi Kwan Wong Hubiao Chen Zhaoxiang Bian Ge Zhang Xue Zhang Muhammad Kashif Riaz Deependra Tyagi Ge Lin Yanbo Zhang Jinjin Wang Aiping Lu Zhijun Yang Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
description	Abstract Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to the lung by targeting a recognition factor present on the surface of lung tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed on the surface of lung cancer cells with a restricted expression in normal lungs. Here, we explored the utility of anti-carbonic anhydrase IX (CA IX) antibody, conjugated to the surface of triptolide (TPL)-loaded liposomes (CA IX-TPL-Lips), to promote the therapeutic effects for lung cancer via pulmonary administration. It was found that the CA IX-TPL-Lips significantly improved the cellular uptake efficiency in both CA IX-positive human non-small cell lung cancer cells (A549) and A549 tumor spheroids, resulting in the efficient cell killing compared with free TPL and non-targeted TPL-Lips. In vivo, CA IX-Lips via pulmonary delivery showed specificity and a sustained release property resided up to 96 h in the lung, both of which improved the efficiency of TPL formulations in restraining tumor growth and significantly prolonged the lifespan of mice with orthotopic lung tumors. The results suggest that CA IX-decorated liposomes can potentially be used as an effective therapeutic strategy for lung cancer.
format	article
author	Congcong Lin Blenda Chi Kwan Wong Hubiao Chen Zhaoxiang Bian Ge Zhang Xue Zhang Muhammad Kashif Riaz Deependra Tyagi Ge Lin Yanbo Zhang Jinjin Wang Aiping Lu Zhijun Yang
author_facet	Congcong Lin Blenda Chi Kwan Wong Hubiao Chen Zhaoxiang Bian Ge Zhang Xue Zhang Muhammad Kashif Riaz Deependra Tyagi Ge Lin Yanbo Zhang Jinjin Wang Aiping Lu Zhijun Yang
author_sort	Congcong Lin
title	Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
title_short	Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
title_full	Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
title_fullStr	Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
title_full_unstemmed	Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy
title_sort	pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase ix antibody for lung cancer therapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7d4a030eccf4f6397379584c5f7a4bf
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Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy

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