Ethanolamine Utilization in Bacteria

ABSTRACT Ethanolamine (EA) is a valuable source of carbon and/or nitrogen for bacteria capable of its catabolism. Because it is derived from the membrane phospholipid phosphatidylethanolamine, it is particularly prevalent in the gastrointestinal tract, which is membrane rich due to turnover of the i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Karan Gautam Kaval, Danielle A. Garsin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	catabolism ethanolamine gene regulation microbial pathogenesis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f7d64c9bb0624310ba5ac5683a790bef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7d64c9bb0624310ba5ac5683a790bef
record_format	dspace
spelling	oai:doaj.org-article:f7d64c9bb0624310ba5ac5683a790bef2021-11-15T15:53:26ZEthanolamine Utilization in Bacteria10.1128/mBio.00066-182150-7511https://doaj.org/article/f7d64c9bb0624310ba5ac5683a790bef2018-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00066-18https://doaj.org/toc/2150-7511ABSTRACT Ethanolamine (EA) is a valuable source of carbon and/or nitrogen for bacteria capable of its catabolism. Because it is derived from the membrane phospholipid phosphatidylethanolamine, it is particularly prevalent in the gastrointestinal tract, which is membrane rich due to turnover of the intestinal epithelium and the resident microbiota. Intriguingly, many gut pathogens carry the eut (ethanolamine utilization) genes. EA utilization has been studied for about 50 years, with most of the early work occurring in just a couple of species of Enterobacteriaceae. Once the metabolic pathways and enzymes were characterized by biochemical approaches, genetic screens were used to map the various activities to the eut genes. With the rise of genomics, the diversity of bacteria containing the eut genes and surprising differences in eut gene content were recognized. Some species contain nearly 20 genes and encode many accessory proteins, while others contain only the core catabolic enzyme. Moreover, the eut genes are regulated by very different mechanisms, depending on the organism and the eut regulator encoded. In the last several years, exciting progress has been made in elucidating the complex regulatory mechanisms that govern eut gene expression. Furthermore, a new appreciation for how EA contributes to infection and colonization in the host is emerging. In addition to providing an overview of EA-related biology, this minireview will give special attention to these recent advances.Karan Gautam KavalDanielle A. GarsinAmerican Society for Microbiologyarticlecatabolismethanolaminegene regulationmicrobial pathogenesisMicrobiologyQR1-502ENmBio, Vol 9, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	catabolism ethanolamine gene regulation microbial pathogenesis Microbiology QR1-502
spellingShingle	catabolism ethanolamine gene regulation microbial pathogenesis Microbiology QR1-502 Karan Gautam Kaval Danielle A. Garsin Ethanolamine Utilization in Bacteria
description	ABSTRACT Ethanolamine (EA) is a valuable source of carbon and/or nitrogen for bacteria capable of its catabolism. Because it is derived from the membrane phospholipid phosphatidylethanolamine, it is particularly prevalent in the gastrointestinal tract, which is membrane rich due to turnover of the intestinal epithelium and the resident microbiota. Intriguingly, many gut pathogens carry the eut (ethanolamine utilization) genes. EA utilization has been studied for about 50 years, with most of the early work occurring in just a couple of species of Enterobacteriaceae. Once the metabolic pathways and enzymes were characterized by biochemical approaches, genetic screens were used to map the various activities to the eut genes. With the rise of genomics, the diversity of bacteria containing the eut genes and surprising differences in eut gene content were recognized. Some species contain nearly 20 genes and encode many accessory proteins, while others contain only the core catabolic enzyme. Moreover, the eut genes are regulated by very different mechanisms, depending on the organism and the eut regulator encoded. In the last several years, exciting progress has been made in elucidating the complex regulatory mechanisms that govern eut gene expression. Furthermore, a new appreciation for how EA contributes to infection and colonization in the host is emerging. In addition to providing an overview of EA-related biology, this minireview will give special attention to these recent advances.
format	article
author	Karan Gautam Kaval Danielle A. Garsin
author_facet	Karan Gautam Kaval Danielle A. Garsin
author_sort	Karan Gautam Kaval
title	Ethanolamine Utilization in Bacteria
title_short	Ethanolamine Utilization in Bacteria
title_full	Ethanolamine Utilization in Bacteria
title_fullStr	Ethanolamine Utilization in Bacteria
title_full_unstemmed	Ethanolamine Utilization in Bacteria
title_sort	ethanolamine utilization in bacteria
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/f7d64c9bb0624310ba5ac5683a790bef
work_keys_str_mv	AT karangautamkaval ethanolamineutilizationinbacteria AT danielleagarsin ethanolamineutilizationinbacteria
_version_	1718427314854821888

Ethanolamine Utilization in Bacteria

Ejemplares similares