Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, heart and peritoneum of otherwise healthy mice.

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Autores principales: Rocío Rojo, Anna Raper, Derya D. Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Melanie Caruso, Iveta Gazova, Alejandra Sánchez, Zofia M. Lisowski, Joana Alves, Irene Molina-Gonzalez, Hayk Davtyan, Rebecca J. Lodge, James D. Glover, Robert Wallace, David A. D. Munro, Eyal David, Ido Amit, Véronique E. Miron, Josef Priller, Stephen J. Jenkins, Giles E. Hardingham, Mathew Blurton-Jones, Neil A. Mabbott, Kim M. Summers, Peter Hohenstein, David A. Hume, Clare Pridans
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f7dcb1c551fc424bb8707e117d441d06
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spelling oai:doaj.org-article:f7dcb1c551fc424bb8707e117d441d062021-12-02T16:58:17ZDeletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations10.1038/s41467-019-11053-82041-1723https://doaj.org/article/f7dcb1c551fc424bb8707e117d441d062019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11053-8https://doaj.org/toc/2041-1723The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, heart and peritoneum of otherwise healthy mice.Rocío RojoAnna RaperDerya D. OzdemirLucas LefevreKathleen GrabertEvi Wollscheid-LengelingBarry BradfordMelanie CarusoIveta GazovaAlejandra SánchezZofia M. LisowskiJoana AlvesIrene Molina-GonzalezHayk DavtyanRebecca J. LodgeJames D. GloverRobert WallaceDavid A. D. MunroEyal DavidIdo AmitVéronique E. MironJosef PrillerStephen J. JenkinsGiles E. HardinghamMathew Blurton-JonesNeil A. MabbottKim M. SummersPeter HohensteinDavid A. HumeClare PridansNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rocío Rojo
Anna Raper
Derya D. Ozdemir
Lucas Lefevre
Kathleen Grabert
Evi Wollscheid-Lengeling
Barry Bradford
Melanie Caruso
Iveta Gazova
Alejandra Sánchez
Zofia M. Lisowski
Joana Alves
Irene Molina-Gonzalez
Hayk Davtyan
Rebecca J. Lodge
James D. Glover
Robert Wallace
David A. D. Munro
Eyal David
Ido Amit
Véronique E. Miron
Josef Priller
Stephen J. Jenkins
Giles E. Hardingham
Mathew Blurton-Jones
Neil A. Mabbott
Kim M. Summers
Peter Hohenstein
David A. Hume
Clare Pridans
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
description The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, heart and peritoneum of otherwise healthy mice.
format article
author Rocío Rojo
Anna Raper
Derya D. Ozdemir
Lucas Lefevre
Kathleen Grabert
Evi Wollscheid-Lengeling
Barry Bradford
Melanie Caruso
Iveta Gazova
Alejandra Sánchez
Zofia M. Lisowski
Joana Alves
Irene Molina-Gonzalez
Hayk Davtyan
Rebecca J. Lodge
James D. Glover
Robert Wallace
David A. D. Munro
Eyal David
Ido Amit
Véronique E. Miron
Josef Priller
Stephen J. Jenkins
Giles E. Hardingham
Mathew Blurton-Jones
Neil A. Mabbott
Kim M. Summers
Peter Hohenstein
David A. Hume
Clare Pridans
author_facet Rocío Rojo
Anna Raper
Derya D. Ozdemir
Lucas Lefevre
Kathleen Grabert
Evi Wollscheid-Lengeling
Barry Bradford
Melanie Caruso
Iveta Gazova
Alejandra Sánchez
Zofia M. Lisowski
Joana Alves
Irene Molina-Gonzalez
Hayk Davtyan
Rebecca J. Lodge
James D. Glover
Robert Wallace
David A. D. Munro
Eyal David
Ido Amit
Véronique E. Miron
Josef Priller
Stephen J. Jenkins
Giles E. Hardingham
Mathew Blurton-Jones
Neil A. Mabbott
Kim M. Summers
Peter Hohenstein
David A. Hume
Clare Pridans
author_sort Rocío Rojo
title Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
title_short Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
title_full Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
title_fullStr Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
title_full_unstemmed Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
title_sort deletion of a csf1r enhancer selectively impacts csf1r expression and development of tissue macrophage populations
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/f7dcb1c551fc424bb8707e117d441d06
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