Research progress on siRNA delivery with nonviral carriers

Yan Gao*, Xin-Ling Liu*, Xiao-Rong LiTianjin Medical University Eye Center, Tianjin, China *These two authors contributed equally to this workAbstract: RNA interference is a powerful method for the knockdown of pathologically relevant genes. Small interfering RNAs (siRNAs) have been widely demonstra...

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Autores principales:	Gao Y, Liu XL, Li XR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7dd0a7eb2154d4e89d92a029a839ab6
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spelling	oai:doaj.org-article:f7dd0a7eb2154d4e89d92a029a839ab62021-12-02T00:12:17ZResearch progress on siRNA delivery with nonviral carriers1176-91141178-2013https://doaj.org/article/f7dd0a7eb2154d4e89d92a029a839ab62011-05-01T00:00:00Zhttp://www.dovepress.com/research-progress-on-sirna-delivery-with-nonviral-carriers-a7431https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yan Gao, Xin-Ling Liu, Xiao-Rong LiTianjin Medical University Eye Center, Tianjin, China *These two authors contributed equally to this workAbstract: RNA interference is a powerful method for the knockdown of pathologically relevant genes. Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical genetic-therapy applications for many diseases. Unfortunately, siRNA duplexes are not ideal drug-like molecules. Problems hindering their effective application fundamentally lie in their delivery, stability, and off-target effects. Delivery systems provide solutions to many of the challenges facing siRNA therapeutics. Due to some fatal disadvantages of viral vectors, nonviral carriers have been studied extensively. Aside from liposomes, nanoparticles and cationic polymer carriers have exhibited improved in vivo stability, better biocompatibility, and efficiency for gene silencing with less cellular toxicity. They may represent a promising strategy for siRNA-based therapies, especially as nanomaterials. The present review also summarizes other methods of siRNA delivery and the side effects of the nanoparticles.Keywords: small interfering RNA, nonviral vector, gene therapy, delivery system, nanoparticles, biocompatibilityGao YLiu XLLi XRDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1017-1025 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gao Y Liu XL Li XR Research progress on siRNA delivery with nonviral carriers
description	Yan Gao, Xin-Ling Liu, Xiao-Rong LiTianjin Medical University Eye Center, Tianjin, China *These two authors contributed equally to this workAbstract: RNA interference is a powerful method for the knockdown of pathologically relevant genes. Small interfering RNAs (siRNAs) have been widely demonstrated as effective biomedical genetic-therapy applications for many diseases. Unfortunately, siRNA duplexes are not ideal drug-like molecules. Problems hindering their effective application fundamentally lie in their delivery, stability, and off-target effects. Delivery systems provide solutions to many of the challenges facing siRNA therapeutics. Due to some fatal disadvantages of viral vectors, nonviral carriers have been studied extensively. Aside from liposomes, nanoparticles and cationic polymer carriers have exhibited improved in vivo stability, better biocompatibility, and efficiency for gene silencing with less cellular toxicity. They may represent a promising strategy for siRNA-based therapies, especially as nanomaterials. The present review also summarizes other methods of siRNA delivery and the side effects of the nanoparticles.Keywords: small interfering RNA, nonviral vector, gene therapy, delivery system, nanoparticles, biocompatibility
format	article
author	Gao Y Liu XL Li XR
author_facet	Gao Y Liu XL Li XR
author_sort	Gao Y
title	Research progress on siRNA delivery with nonviral carriers
title_short	Research progress on siRNA delivery with nonviral carriers
title_full	Research progress on siRNA delivery with nonviral carriers
title_fullStr	Research progress on siRNA delivery with nonviral carriers
title_full_unstemmed	Research progress on siRNA delivery with nonviral carriers
title_sort	research progress on sirna delivery with nonviral carriers
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/f7dd0a7eb2154d4e89d92a029a839ab6
work_keys_str_mv	AT gaoy researchprogressonsirnadeliverywithnonviralcarriers AT liuxl researchprogressonsirnadeliverywithnonviralcarriers AT lixr researchprogressonsirnadeliverywithnonviralcarriers
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Research progress on siRNA delivery with nonviral carriers

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