Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials

Objective: Accumulating evidence has been reported regarding the effect of dietary antioxidants on clinical variables in IBD patients, however, findings are controversial. This systematic review and meta-analysis aimed to investigate effect of dietary antioxidants on clinical variables in patients w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hossein Shahinfar, Nastaran Payandeh, Maryam ElhamKia, Fatemeh Abbasi, Alireza Alaghi, Farhang Djafari, Masoumeh Eslahi, Narjes Sadat Farizani Gohari, Parivash Ghorbaninejad, Mohaddeseh Hasanzadeh, Alireza Jafari, Aliyu Tijani Jibril, Reihane Khorasaniha, Elahe Mansouri, Vahid Monfared, Soroush Rezaee, Adel Salehian, Mahshid Shahavandi, Leila Sheikhi, Alireza Milajerdi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Antioxidants Inflammatory bowel disease Clinical remission Endoscopic remission Meta-analysis Randomized clinical trial Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/f7dd8b794a914141b0ebd0cd8556b2b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7dd8b794a914141b0ebd0cd8556b2b0
record_format	dspace
spelling	oai:doaj.org-article:f7dd8b794a914141b0ebd0cd8556b2b02021-11-06T04:20:52ZAdministration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials0965-229910.1016/j.ctim.2021.102787https://doaj.org/article/f7dd8b794a914141b0ebd0cd8556b2b02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S096522992100128Xhttps://doaj.org/toc/0965-2299Objective: Accumulating evidence has been reported regarding the effect of dietary antioxidants on clinical variables in IBD patients, however, findings are controversial. This systematic review and meta-analysis aimed to investigate effect of dietary antioxidants on clinical variables in patients with IBD or its subtypes. Methods: We searched PubMed, Scopus, and ISI Web of Science from inception to January 2021 using relevant keywords. Data were pooled by using the random-effect model. All statistical analyses were done using STATA version 14. Results: Our meta-analysis was exclusively done on studies about the effect of curcumin on IBD patients, because limited studies were done on other antioxidants. Curcumin administration resulted in significant increment of clinical remission in patients with IBD (SMD: 0.86%, 95% CI: 0.16, 1.56, p = 0.016), significant remission in clinical symptoms (SMD: −0.96 score, 95% CI: −1.34, −0.57, p < 0.001), and significant increment in endoscopic remission in IBD patients (SMD: 0.51%, 95% CI: 0.16, 0.85, p = 0.004), comparing to control group. Curcumin supplementation also made better clinical response than control group (SMD: 0.74%, 95% CI: 0.22, 1.26, p = 0.005) and also resulted in significant improvement in quality of life of patients with IBD, as compared to control group (SMD: 1.23 score, 95% CI: 0.72, 1.74, p < 0.001). Conclusions: Our meta-analysis showed that curcumin significantly improved clinical and endoscopic remissions in IBD patients. This supplementation also caused significant reduction in clinical symptoms of IBD patients along with better clinical response and the increased quality of life. Further researches with larger sample size and longer period of intervention are required to evaluate efficacy of dietary antioxidants on clinical variables in patients with IBD.Hossein ShahinfarNastaran PayandehMaryam ElhamKiaFatemeh AbbasiAlireza AlaghiFarhang DjafariMasoumeh EslahiNarjes Sadat Farizani GohariParivash GhorbaninejadMohaddeseh HasanzadehAlireza JafariAliyu Tijani JibrilReihane KhorasanihaElahe MansouriVahid MonfaredSoroush RezaeeAdel SalehianMahshid ShahavandiLeila SheikhiAlireza MilajerdiElsevierarticleAntioxidantsInflammatory bowel diseaseClinical remissionEndoscopic remissionMeta-analysisRandomized clinical trialOther systems of medicineRZ201-999ENComplementary Therapies in Medicine, Vol 63, Iss , Pp 102787- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antioxidants Inflammatory bowel disease Clinical remission Endoscopic remission Meta-analysis Randomized clinical trial Other systems of medicine RZ201-999
spellingShingle	Antioxidants Inflammatory bowel disease Clinical remission Endoscopic remission Meta-analysis Randomized clinical trial Other systems of medicine RZ201-999 Hossein Shahinfar Nastaran Payandeh Maryam ElhamKia Fatemeh Abbasi Alireza Alaghi Farhang Djafari Masoumeh Eslahi Narjes Sadat Farizani Gohari Parivash Ghorbaninejad Mohaddeseh Hasanzadeh Alireza Jafari Aliyu Tijani Jibril Reihane Khorasaniha Elahe Mansouri Vahid Monfared Soroush Rezaee Adel Salehian Mahshid Shahavandi Leila Sheikhi Alireza Milajerdi Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials
description	Objective: Accumulating evidence has been reported regarding the effect of dietary antioxidants on clinical variables in IBD patients, however, findings are controversial. This systematic review and meta-analysis aimed to investigate effect of dietary antioxidants on clinical variables in patients with IBD or its subtypes. Methods: We searched PubMed, Scopus, and ISI Web of Science from inception to January 2021 using relevant keywords. Data were pooled by using the random-effect model. All statistical analyses were done using STATA version 14. Results: Our meta-analysis was exclusively done on studies about the effect of curcumin on IBD patients, because limited studies were done on other antioxidants. Curcumin administration resulted in significant increment of clinical remission in patients with IBD (SMD: 0.86%, 95% CI: 0.16, 1.56, p = 0.016), significant remission in clinical symptoms (SMD: −0.96 score, 95% CI: −1.34, −0.57, p < 0.001), and significant increment in endoscopic remission in IBD patients (SMD: 0.51%, 95% CI: 0.16, 0.85, p = 0.004), comparing to control group. Curcumin supplementation also made better clinical response than control group (SMD: 0.74%, 95% CI: 0.22, 1.26, p = 0.005) and also resulted in significant improvement in quality of life of patients with IBD, as compared to control group (SMD: 1.23 score, 95% CI: 0.72, 1.74, p < 0.001). Conclusions: Our meta-analysis showed that curcumin significantly improved clinical and endoscopic remissions in IBD patients. This supplementation also caused significant reduction in clinical symptoms of IBD patients along with better clinical response and the increased quality of life. Further researches with larger sample size and longer period of intervention are required to evaluate efficacy of dietary antioxidants on clinical variables in patients with IBD.
format	article
author	Hossein Shahinfar Nastaran Payandeh Maryam ElhamKia Fatemeh Abbasi Alireza Alaghi Farhang Djafari Masoumeh Eslahi Narjes Sadat Farizani Gohari Parivash Ghorbaninejad Mohaddeseh Hasanzadeh Alireza Jafari Aliyu Tijani Jibril Reihane Khorasaniha Elahe Mansouri Vahid Monfared Soroush Rezaee Adel Salehian Mahshid Shahavandi Leila Sheikhi Alireza Milajerdi
author_facet	Hossein Shahinfar Nastaran Payandeh Maryam ElhamKia Fatemeh Abbasi Alireza Alaghi Farhang Djafari Masoumeh Eslahi Narjes Sadat Farizani Gohari Parivash Ghorbaninejad Mohaddeseh Hasanzadeh Alireza Jafari Aliyu Tijani Jibril Reihane Khorasaniha Elahe Mansouri Vahid Monfared Soroush Rezaee Adel Salehian Mahshid Shahavandi Leila Sheikhi Alireza Milajerdi
author_sort	Hossein Shahinfar
title	Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials
title_short	Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials
title_full	Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials
title_fullStr	Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials
title_full_unstemmed	Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials
title_sort	administration of dietary antioxidants for patients with inflammatory bowel disease: a systematic review and meta-analysis of randomized controlled clinical trials
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f7dd8b794a914141b0ebd0cd8556b2b0
work_keys_str_mv	AT hosseinshahinfar administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT nastaranpayandeh administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT maryamelhamkia administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT fatemehabbasi administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT alirezaalaghi administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT farhangdjafari administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT masoumeheslahi administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT narjessadatfarizanigohari administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT parivashghorbaninejad administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT mohaddesehhasanzadeh administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT alirezajafari administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT aliyutijanijibril administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT reihanekhorasaniha administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT elahemansouri administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT vahidmonfared administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT soroushrezaee administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT adelsalehian administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT mahshidshahavandi administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT leilasheikhi administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials AT alirezamilajerdi administrationofdietaryantioxidantsforpatientswithinflammatoryboweldiseaseasystematicreviewandmetaanalysisofrandomizedcontrolledclinicaltrials
_version_	1718443955596558336

Administration of dietary antioxidants for patients with inflammatory bowel disease: A systematic review and meta-analysis of randomized controlled clinical trials

Ejemplares similares