Galanin Receptors as Drug Target for Novel Antidepressants: Review

Desalegn Getnet Demsie,1 Birhanetensay Masresha Altaye,2 Etsay Weldekidan,1 Hagazi Gebremedhin,1 Niguse Meles Alema,3 Mulugeta Mihrete Tefera,3 Abere Tilahun Bantie4 1College of Medicine and Health Sciences, Department of Pharmacy, Adigrat University, Adigrat, Ethiopia; 2College of Health Sciences,...

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Autores principales:	Demsie DG, Altaye BM, Weldekidan E, Gebremedhin H, Alema NM, Tefera MM, Bantie AT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	galanin depression galanin receptors Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7df9e2cd2024a7f855b56ad4fee7d18
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spelling	oai:doaj.org-article:f7df9e2cd2024a7f855b56ad4fee7d182021-12-02T09:56:38ZGalanin Receptors as Drug Target for Novel Antidepressants: Review1177-5491https://doaj.org/article/f7df9e2cd2024a7f855b56ad4fee7d182020-04-01T00:00:00Zhttps://www.dovepress.com/galanin-receptors-as-drug-target-for-novel-antidepressants-review-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Desalegn Getnet Demsie,1 Birhanetensay Masresha Altaye,2 Etsay Weldekidan,1 Hagazi Gebremedhin,1 Niguse Meles Alema,3 Mulugeta Mihrete Tefera,3 Abere Tilahun Bantie4 1College of Medicine and Health Sciences, Department of Pharmacy, Adigrat University, Adigrat, Ethiopia; 2College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 3Bahir Dar Health Science College, Bahir Dar, Ethiopia; 4College of Medicine and Health Sciences, Department of Anesthesia, Adigrat University, Adigrat, EthiopiaCorrespondence: Desalegn Getnet Demsie Tel +251 937404956Email desget361@gmail.comAbstract: Galanin (GAL) is a 29-amino-acid neuropeptide that serves multiple physiological functions throughout the central and peripheral nervous system. Its role involves in a range of physiological and pathological functions including control of food intake, neuro-protection, neuronal regeneration, energy expenditure, reproduction, water balance, mood, nociception and various neuroendocrine functions. The use of currently available antidepressant drugs raises concerns regarding efficacy and onset of action; therefore, the need for antidepressants with novel mechanisms is increasing. Presently, various studies revealed the link between GAL and depression. Attenuation of depressive symptoms is achieved through inhibition of GalR1 and GalR3 and activation of GalR2. However, lack of receptor selectivity of ligands has limited the complete elucidation of effects of different receptors in depression-like behavior. Studies have suggested that GAL enhances the action of selective serotonin reuptake inhibitors (SSRIs) and promotes availability of transcription proteins. This review addresses the role of GAL, GAL receptors (GALRs) ligands including selective peptides, and the mechanism of ligand receptor interaction in attenuating depressive symptoms.Keywords: Galanin (GAL), depression, Galanin (GAL) receptorsDemsie DGAltaye BMWeldekidan EGebremedhin HAlema NMTefera MMBantie ATDove Medical Pressarticlegalanindepressiongalanin receptorsMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 14, Pp 37-45 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	galanin depression galanin receptors Medicine (General) R5-920
spellingShingle	galanin depression galanin receptors Medicine (General) R5-920 Demsie DG Altaye BM Weldekidan E Gebremedhin H Alema NM Tefera MM Bantie AT Galanin Receptors as Drug Target for Novel Antidepressants: Review
description	Desalegn Getnet Demsie,1 Birhanetensay Masresha Altaye,2 Etsay Weldekidan,1 Hagazi Gebremedhin,1 Niguse Meles Alema,3 Mulugeta Mihrete Tefera,3 Abere Tilahun Bantie4 1College of Medicine and Health Sciences, Department of Pharmacy, Adigrat University, Adigrat, Ethiopia; 2College of Health Sciences, Debre Berhan University, Debre Berhan, Ethiopia; 3Bahir Dar Health Science College, Bahir Dar, Ethiopia; 4College of Medicine and Health Sciences, Department of Anesthesia, Adigrat University, Adigrat, EthiopiaCorrespondence: Desalegn Getnet Demsie Tel +251 937404956Email desget361@gmail.comAbstract: Galanin (GAL) is a 29-amino-acid neuropeptide that serves multiple physiological functions throughout the central and peripheral nervous system. Its role involves in a range of physiological and pathological functions including control of food intake, neuro-protection, neuronal regeneration, energy expenditure, reproduction, water balance, mood, nociception and various neuroendocrine functions. The use of currently available antidepressant drugs raises concerns regarding efficacy and onset of action; therefore, the need for antidepressants with novel mechanisms is increasing. Presently, various studies revealed the link between GAL and depression. Attenuation of depressive symptoms is achieved through inhibition of GalR1 and GalR3 and activation of GalR2. However, lack of receptor selectivity of ligands has limited the complete elucidation of effects of different receptors in depression-like behavior. Studies have suggested that GAL enhances the action of selective serotonin reuptake inhibitors (SSRIs) and promotes availability of transcription proteins. This review addresses the role of GAL, GAL receptors (GALRs) ligands including selective peptides, and the mechanism of ligand receptor interaction in attenuating depressive symptoms.Keywords: Galanin (GAL), depression, Galanin (GAL) receptors
format	article
author	Demsie DG Altaye BM Weldekidan E Gebremedhin H Alema NM Tefera MM Bantie AT
author_facet	Demsie DG Altaye BM Weldekidan E Gebremedhin H Alema NM Tefera MM Bantie AT
author_sort	Demsie DG
title	Galanin Receptors as Drug Target for Novel Antidepressants: Review
title_short	Galanin Receptors as Drug Target for Novel Antidepressants: Review
title_full	Galanin Receptors as Drug Target for Novel Antidepressants: Review
title_fullStr	Galanin Receptors as Drug Target for Novel Antidepressants: Review
title_full_unstemmed	Galanin Receptors as Drug Target for Novel Antidepressants: Review
title_sort	galanin receptors as drug target for novel antidepressants: review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f7df9e2cd2024a7f855b56ad4fee7d18
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Galanin Receptors as Drug Target for Novel Antidepressants: Review

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