New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression

Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers. The regulation of YAP1 phosphorylation, YAP1 expressionlevel, and its cellular localization hav...

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Autores principales:	Fariba Dehghanian, Zahra Azhir, Atefeh Akbari, Zohreh Hojati
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2019
Materias:	yap1 colorectal cancer hippo pathway lncrnas mirnas circrnas Medicine R
Acceso en línea:	https://doaj.org/article/f7dfb7b0843049ffab5e42991fb0cbe9
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spelling	oai:doaj.org-article:f7dfb7b0843049ffab5e42991fb0cbe92021-11-14T08:42:16ZNew Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression2783-2430https://doaj.org/article/f7dfb7b0843049ffab5e42991fb0cbe92019-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46321_d957ae169c6ca8bd80619084f1ba2e78.pdfhttps://doaj.org/toc/2783-2430Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers. The regulation of YAP1 phosphorylation, YAP1 expressionlevel, and its cellular localization have been considered in cancer development. There are different experimental evidences thatindicate that YAP1 activation results in tumorigenesis, tumor progression, and metastasis. YAP1 is a transcription co-activator, andits dysregulation has been suggested in various cancers including colorectal cancer (CRC). The localization of YAP1 in the nucleusresults in YAP1 interactions with different transcription factors to promote the expression of genes involved in cell proliferation,metastasis, and stem cell maintenance. However, a number of studies have been reported the tumor suppressor role of YAP1 in CRC.Therefore, a better understanding of the YAP1 regulation could be helpful for prevention, diagnosis, and treatment of CRC. In thisreview, we will discuss different roles of YAP1 in CRC progression through the regulatory roles of long non-coding RNAs (LncRNAs),microRNAs (miRNAs) and circular RNAs (CircRNAs) in YAP1 regulation.Fariba DehghanianZahra AzhirAtefeh AkbariZohreh HojatiShiraz University of Medical Sciencesarticleyap1colorectal cancerhippo pathwaylncrnasmirnascircrnasMedicineRENIranian Journal of Colorectal Research, Vol 7, Iss 2, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	yap1 colorectal cancer hippo pathway lncrnas mirnas circrnas Medicine R
spellingShingle	yap1 colorectal cancer hippo pathway lncrnas mirnas circrnas Medicine R Fariba Dehghanian Zahra Azhir Atefeh Akbari Zohreh Hojati New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression
description	Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers. The regulation of YAP1 phosphorylation, YAP1 expressionlevel, and its cellular localization have been considered in cancer development. There are different experimental evidences thatindicate that YAP1 activation results in tumorigenesis, tumor progression, and metastasis. YAP1 is a transcription co-activator, andits dysregulation has been suggested in various cancers including colorectal cancer (CRC). The localization of YAP1 in the nucleusresults in YAP1 interactions with different transcription factors to promote the expression of genes involved in cell proliferation,metastasis, and stem cell maintenance. However, a number of studies have been reported the tumor suppressor role of YAP1 in CRC.Therefore, a better understanding of the YAP1 regulation could be helpful for prevention, diagnosis, and treatment of CRC. In thisreview, we will discuss different roles of YAP1 in CRC progression through the regulatory roles of long non-coding RNAs (LncRNAs),microRNAs (miRNAs) and circular RNAs (CircRNAs) in YAP1 regulation.
format	article
author	Fariba Dehghanian Zahra Azhir Atefeh Akbari Zohreh Hojati
author_facet	Fariba Dehghanian Zahra Azhir Atefeh Akbari Zohreh Hojati
author_sort	Fariba Dehghanian
title	New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression
title_short	New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression
title_full	New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression
title_fullStr	New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression
title_full_unstemmed	New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression
title_sort	new insights into the roles of yes-associated protein (yap1) in colorectal cancer development and progression
publisher	Shiraz University of Medical Sciences
publishDate	2019
url	https://doaj.org/article/f7dfb7b0843049ffab5e42991fb0cbe9
work_keys_str_mv	AT faribadehghanian newinsightsintotherolesofyesassociatedproteinyap1incolorectalcancerdevelopmentandprogression AT zahraazhir newinsightsintotherolesofyesassociatedproteinyap1incolorectalcancerdevelopmentandprogression AT atefehakbari newinsightsintotherolesofyesassociatedproteinyap1incolorectalcancerdevelopmentandprogression AT zohrehhojati newinsightsintotherolesofyesassociatedproteinyap1incolorectalcancerdevelopmentandprogression
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New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression

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