Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease

The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer’s disease (AD). Several neuroactive compounds and their signaling pathways through various types of receptors are crucial in brain homeostasis, among them glutamate and γ-aminobutyric acid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Grzegorz A. Czapski, Joanna B. Strosznajder
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Alzheimer’s disease glutamate GABA microglia neurons neurotransmission Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f7e2d4cad42643a1ba0a14d86c499bde
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7e2d4cad42643a1ba0a14d86c499bde
record_format	dspace
spelling	oai:doaj.org-article:f7e2d4cad42643a1ba0a14d86c499bde2021-11-11T17:08:24ZGlutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease10.3390/ijms2221116771422-00671661-6596https://doaj.org/article/f7e2d4cad42643a1ba0a14d86c499bde2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11677https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer’s disease (AD). Several neuroactive compounds and their signaling pathways through various types of receptors are crucial in brain homeostasis, among them glutamate and γ-aminobutyric acid (GABA). Activation of microglial receptors regulates the immunological response of these cells, which in AD could be neuroprotective or neurotoxic. The novel research approaches revealed the complexity of microglial function, including the interplay with other cells during neuroinflammation and in the AD brain. The purpose of this review is to describe the role of several proteins and multiple receptors on microglia and neurons, and their involvement in a communication network between cells that could lead to different metabolic loops and cell death/survival. Our review is focused on the role of glutamatergic, GABAergic signaling in microglia–neuronal cross-talk in AD and neuroinflammation. Moreover, the significance of AD-related neurotoxic proteins in glutamate/GABA-mediated dialogue between microglia and neurons was analyzed in search of novel targets in neuroprotection, and advanced pharmacological approaches.Grzegorz A. CzapskiJoanna B. StrosznajderMDPI AGarticleAlzheimer’s diseaseglutamateGABAmicroglianeuronsneurotransmissionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11677, p 11677 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease glutamate GABA microglia neurons neurotransmission Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	Alzheimer’s disease glutamate GABA microglia neurons neurotransmission Biology (General) QH301-705.5 Chemistry QD1-999 Grzegorz A. Czapski Joanna B. Strosznajder Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
description	The physiological balance between excitation and inhibition in the brain is significantly affected in Alzheimer’s disease (AD). Several neuroactive compounds and their signaling pathways through various types of receptors are crucial in brain homeostasis, among them glutamate and γ-aminobutyric acid (GABA). Activation of microglial receptors regulates the immunological response of these cells, which in AD could be neuroprotective or neurotoxic. The novel research approaches revealed the complexity of microglial function, including the interplay with other cells during neuroinflammation and in the AD brain. The purpose of this review is to describe the role of several proteins and multiple receptors on microglia and neurons, and their involvement in a communication network between cells that could lead to different metabolic loops and cell death/survival. Our review is focused on the role of glutamatergic, GABAergic signaling in microglia–neuronal cross-talk in AD and neuroinflammation. Moreover, the significance of AD-related neurotoxic proteins in glutamate/GABA-mediated dialogue between microglia and neurons was analyzed in search of novel targets in neuroprotection, and advanced pharmacological approaches.
format	article
author	Grzegorz A. Czapski Joanna B. Strosznajder
author_facet	Grzegorz A. Czapski Joanna B. Strosznajder
author_sort	Grzegorz A. Czapski
title	Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
title_short	Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
title_full	Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
title_fullStr	Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
title_full_unstemmed	Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
title_sort	glutamate and gaba in microglia-neuron cross-talk in alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f7e2d4cad42643a1ba0a14d86c499bde
work_keys_str_mv	AT grzegorzaczapski glutamateandgabainmicroglianeuroncrosstalkinalzheimersdisease AT joannabstrosznajder glutamateandgabainmicroglianeuroncrosstalkinalzheimersdisease
_version_	1718432215543578624

Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease

Ejemplares similares