Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor

Little is known about the molecular mechanisms regulating neuron-specific alternative splicing. Here, the authors identify a combination of RNA-binding proteins regulating neuron-specific expression of the C. elegansinsulin receptor isoform DAF-2c and find disrupting these factors leads to learning...

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Bibliographic Details
Main Authors: Masahiro Tomioka, Yasuki Naito, Hidehito Kuroyanagi, Yuichi Iino
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/f7e369aae40f41fea88f2ff8964a662b
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Summary:Little is known about the molecular mechanisms regulating neuron-specific alternative splicing. Here, the authors identify a combination of RNA-binding proteins regulating neuron-specific expression of the C. elegansinsulin receptor isoform DAF-2c and find disrupting these factors leads to learning deficits.