Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression

Abstract Repeated transcranial magnetic stimulation (rTMS) is a therapeutic brain-stimulation technique that is particularly used for drug-resistant depressive disorders. European recommendations mention the effectiveness of 30 to 64%. The failure rate of treatment is high and clinical improvement i...

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Autores principales:	Aurélie Lacroix, Benjamin Calvet, Benjamin Laplace, Marilyne Lannaud, Brigitte Plansont, Sandrine Guignandon, Patrice Balestrat, Murielle Girard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f7e70073fb2a40c297341aa2389b336a
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spelling	oai:doaj.org-article:f7e70073fb2a40c297341aa2389b336a2021-11-21T12:07:46ZPredictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression10.1038/s41398-021-01555-92158-3188https://doaj.org/article/f7e70073fb2a40c297341aa2389b336a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01555-9https://doaj.org/toc/2158-3188Abstract Repeated transcranial magnetic stimulation (rTMS) is a therapeutic brain-stimulation technique that is particularly used for drug-resistant depressive disorders. European recommendations mention the effectiveness of 30 to 64%. The failure rate of treatment is high and clinical improvement is visible only after a certain period of time. It would thus be useful to have indicators that could anticipate the success of treatment and more effectively guide therapeutic choices. We aimed to find predictive indicators of clinical improvement at 1 month after the start of rTMS treatment among the data collected during the care of patients with drug-resistant depression included in the Neuromodulation Unit of the Esquirol Hospital in Limoges since 2007. In total, 290 patients with a pharmaco-resistant depressive episode, according to the Hamilton Depression Rating Scale (HDRS) (score ≥8), before treatment who underwent a complete course of rTMS treatment and did not object to the use of their collected data were included. The clinical response in routine practice, corresponding to a decrease in the HDRS score of at least 50% from inclusion, was determined and complemented by interquartile analysis. A combination of factors predictive of clinical response during care, such as a short duration of the current depressive episode associated with a higher HDRS agitation item value (or a lower perceived sleepiness value) and a higher number of previous rTMS treatments, were identified as being useful in predicting the efficacy of rTMS treatment in routine clinical practice, thus facilitating the therapeutic choice for patients with drug-resistant depression.Aurélie LacroixBenjamin CalvetBenjamin LaplaceMarilyne LannaudBrigitte PlansontSandrine GuignandonPatrice BalestratMurielle GirardNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Aurélie Lacroix Benjamin Calvet Benjamin Laplace Marilyne Lannaud Brigitte Plansont Sandrine Guignandon Patrice Balestrat Murielle Girard Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression
description	Abstract Repeated transcranial magnetic stimulation (rTMS) is a therapeutic brain-stimulation technique that is particularly used for drug-resistant depressive disorders. European recommendations mention the effectiveness of 30 to 64%. The failure rate of treatment is high and clinical improvement is visible only after a certain period of time. It would thus be useful to have indicators that could anticipate the success of treatment and more effectively guide therapeutic choices. We aimed to find predictive indicators of clinical improvement at 1 month after the start of rTMS treatment among the data collected during the care of patients with drug-resistant depression included in the Neuromodulation Unit of the Esquirol Hospital in Limoges since 2007. In total, 290 patients with a pharmaco-resistant depressive episode, according to the Hamilton Depression Rating Scale (HDRS) (score ≥8), before treatment who underwent a complete course of rTMS treatment and did not object to the use of their collected data were included. The clinical response in routine practice, corresponding to a decrease in the HDRS score of at least 50% from inclusion, was determined and complemented by interquartile analysis. A combination of factors predictive of clinical response during care, such as a short duration of the current depressive episode associated with a higher HDRS agitation item value (or a lower perceived sleepiness value) and a higher number of previous rTMS treatments, were identified as being useful in predicting the efficacy of rTMS treatment in routine clinical practice, thus facilitating the therapeutic choice for patients with drug-resistant depression.
format	article
author	Aurélie Lacroix Benjamin Calvet Benjamin Laplace Marilyne Lannaud Brigitte Plansont Sandrine Guignandon Patrice Balestrat Murielle Girard
author_facet	Aurélie Lacroix Benjamin Calvet Benjamin Laplace Marilyne Lannaud Brigitte Plansont Sandrine Guignandon Patrice Balestrat Murielle Girard
author_sort	Aurélie Lacroix
title	Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression
title_short	Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression
title_full	Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression
title_fullStr	Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression
title_full_unstemmed	Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression
title_sort	predictors of clinical response after rtms treatment of patients suffering from drug-resistant depression
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f7e70073fb2a40c297341aa2389b336a
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Predictors of clinical response after rTMS treatment of patients suffering from drug-resistant depression

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