Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages

Abstract Cholesterol efflux capacity (CEC) from macrophages, the first step in the reverse cholesterol transport pathway, is inversely associated with residual risk for atherosclerotic cardiovascular disease. Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macroph...

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Autores principales:	Masato Furuhashi, Masatsune Ogura, Megumi Matsumoto, Satoshi Yuda, Atsuko Muranaka, Mina Kawamukai, Akina Omori, Marenao Tanaka, Norihito Moniwa, Hirofumi Ohnishi, Shigeyuki Saitoh, Mariko Harada-Shiba, Kazuaki Shimamoto, Tetsuji Miura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7e78848e7db4a6992e2d980ee8c9716
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spelling	oai:doaj.org-article:f7e78848e7db4a6992e2d980ee8c97162021-12-02T12:32:39ZSerum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages10.1038/s41598-017-00177-w2045-2322https://doaj.org/article/f7e78848e7db4a6992e2d980ee8c97162017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00177-whttps://doaj.org/toc/2045-2322Abstract Cholesterol efflux capacity (CEC) from macrophages, the first step in the reverse cholesterol transport pathway, is inversely associated with residual risk for atherosclerotic cardiovascular disease. Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and play significant roles in the development of insulin resistance and atherosclerosis. Both FABP4 and FABP5 are secreted from cells, and their circulating levels are associated with insulin resistance and atherosclerosis. We investigated the association between CEC and levels of FABP4 and FABP5 in 250 subjects without any medications. CEC was positively correlated with HDL cholesterol level and negatively correlated with concentrations of high-sensitivity C-reactive protein (hsCRP) and FABP5, but not FABP4. Multiple regression analysis demonstrated that FABP5 concentration was an independent predictor of CEC after adjustment of age, gender and levels of HDL cholesterol and hsCRP. In 129 of the 250 subjects who underwent carotid ultrasonography, mean intima-media thickness was negatively correlated with CEC and was positively correlated with concentrations of FABP4 and FABP5. In conclusion, in contrast to FABP4, circulating FABP5 is associated with decreased CEC and carotid atherosclerosis, suggesting that FABP5 level is a regulatory factor of CEC and a potential biomarker for residual risk of atherosclerosis.Masato FuruhashiMasatsune OguraMegumi MatsumotoSatoshi YudaAtsuko MuranakaMina KawamukaiAkina OmoriMarenao TanakaNorihito MoniwaHirofumi OhnishiShigeyuki SaitohMariko Harada-ShibaKazuaki ShimamotoTetsuji MiuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masato Furuhashi Masatsune Ogura Megumi Matsumoto Satoshi Yuda Atsuko Muranaka Mina Kawamukai Akina Omori Marenao Tanaka Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Mariko Harada-Shiba Kazuaki Shimamoto Tetsuji Miura Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
description	Abstract Cholesterol efflux capacity (CEC) from macrophages, the first step in the reverse cholesterol transport pathway, is inversely associated with residual risk for atherosclerotic cardiovascular disease. Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and play significant roles in the development of insulin resistance and atherosclerosis. Both FABP4 and FABP5 are secreted from cells, and their circulating levels are associated with insulin resistance and atherosclerosis. We investigated the association between CEC and levels of FABP4 and FABP5 in 250 subjects without any medications. CEC was positively correlated with HDL cholesterol level and negatively correlated with concentrations of high-sensitivity C-reactive protein (hsCRP) and FABP5, but not FABP4. Multiple regression analysis demonstrated that FABP5 concentration was an independent predictor of CEC after adjustment of age, gender and levels of HDL cholesterol and hsCRP. In 129 of the 250 subjects who underwent carotid ultrasonography, mean intima-media thickness was negatively correlated with CEC and was positively correlated with concentrations of FABP4 and FABP5. In conclusion, in contrast to FABP4, circulating FABP5 is associated with decreased CEC and carotid atherosclerosis, suggesting that FABP5 level is a regulatory factor of CEC and a potential biomarker for residual risk of atherosclerosis.
format	article
author	Masato Furuhashi Masatsune Ogura Megumi Matsumoto Satoshi Yuda Atsuko Muranaka Mina Kawamukai Akina Omori Marenao Tanaka Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Mariko Harada-Shiba Kazuaki Shimamoto Tetsuji Miura
author_facet	Masato Furuhashi Masatsune Ogura Megumi Matsumoto Satoshi Yuda Atsuko Muranaka Mina Kawamukai Akina Omori Marenao Tanaka Norihito Moniwa Hirofumi Ohnishi Shigeyuki Saitoh Mariko Harada-Shiba Kazuaki Shimamoto Tetsuji Miura
author_sort	Masato Furuhashi
title	Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
title_short	Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
title_full	Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
title_fullStr	Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
title_full_unstemmed	Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
title_sort	serum fabp5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7e78848e7db4a6992e2d980ee8c9716
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Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages

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