Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study

Shao-Hua Hu,1,2 Hong Feng,3,4 Ting-Ting Xu,3,5 Hao-Rong Zhang,6 Zhi-Yong Zhao,6 Jian-Bo Lai,1,2 Dong-Rong Xu,7 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 2The Key Laboratory of Mental Disorder’s Management of Zhejiang P...

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Autores principales:	Hu SH, Feng H, Xu TT, Zhang HR, Zhao ZY, Lai JB, Xu DR, Xu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	anorexia nervosa magnetic resonance imaging diffusion tension imaging white matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/f7e94a93793048abb895af0e247aa3fa
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spelling	oai:doaj.org-article:f7e94a93793048abb895af0e247aa3fa2021-12-02T01:04:41ZAltered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study1178-2021https://doaj.org/article/f7e94a93793048abb895af0e247aa3fa2017-11-01T00:00:00Zhttps://www.dovepress.com/altered-microstructure-of-brain-white-matter-in-females-with-anorexia--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shao-Hua Hu,1,2 Hong Feng,3,4 Ting-Ting Xu,3,5 Hao-Rong Zhang,6 Zhi-Yong Zhao,6 Jian-Bo Lai,1,2 Dong-Rong Xu,7 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, 3Faculty of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, 4Department of Psychiatry, Shaoxing No Seven People’s Hospital, Shaoxing, 5Department of Psychiatry, The Center of Mental Health, Xiaoshan Hospital, Hangzhou, 6Shanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Function Genomics, East China Normal University, Shanghai, China; 7Epidemiology Division and MRI Unit, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA Objective: Structural studies have reported anorexia nervosa (AN) patients with abnormal gray matter in several brain regions and dysfunction in some connected neural circuits. However, the role of white matter (WM) in AN patients has rarely been investigated. The present study aimed to assess alterations in WM microstructure of the entire brain in females with AN using a voxel-based method on diffusion tensor imaging (DTI) data.Materials and methods: The study enrolled 8 female patients with AN and 14 age-matched females as controls (CW). The DTI data was collected from each subject to calculate the fractional anisotropy (FA) maps of the whole brain by the DTI-Studio software. Subsequently, a 2-sample t-test (P<0.05, corrected) was performed to detect the difference in FA maps of AN and CW group, and a Pearson’s correlation analyzed the relationship between mean FA value of brain regions and body mass index (BMI).Results: Compared with CW, AN patients revealed a significant decrease in FA maps in the left superior frontal gyrus, medial frontal gyrus, anterior cingulate cortex, middle frontal gyrus, inferior frontal gyrus, thalamus, and bilateral insula. Moreover, significantly positive correlations were established between the mean FA value of the left inferior frontal gyrus, insula as well as thalamus and BMI in AN patients.Conclusions: Our findings supported the presence of WM abnormality in patients with AN. The significant differences of FA maps, in patients with AN, were associated with their aberrant BMI. The results further improved our understanding of the pathophysiological mechanisms underlying AN. Keywords: anorexia nervosa, magnetic resonance imaging, diffusion tensor imaging, white matter Hu SHFeng HXu TTZhang HRZhao ZYLai JBXu DRXu YDove Medical Pressarticleanorexia nervosamagnetic resonance imagingdiffusion tension imagingwhite matterNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2829-2836 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	anorexia nervosa magnetic resonance imaging diffusion tension imaging white matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	anorexia nervosa magnetic resonance imaging diffusion tension imaging white matter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Hu SH Feng H Xu TT Zhang HR Zhao ZY Lai JB Xu DR Xu Y Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
description	Shao-Hua Hu,1,2 Hong Feng,3,4 Ting-Ting Xu,3,5 Hao-Rong Zhang,6 Zhi-Yong Zhao,6 Jian-Bo Lai,1,2 Dong-Rong Xu,7 Yi Xu1,2 1Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, 3Faculty of Clinical Medicine, Zhejiang University School of Medicine, Hangzhou, 4Department of Psychiatry, Shaoxing No Seven People’s Hospital, Shaoxing, 5Department of Psychiatry, The Center of Mental Health, Xiaoshan Hospital, Hangzhou, 6Shanghai Key Laboratory of Magnetic Resonance, Key Laboratory of Brain Function Genomics, East China Normal University, Shanghai, China; 7Epidemiology Division and MRI Unit, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA Objective: Structural studies have reported anorexia nervosa (AN) patients with abnormal gray matter in several brain regions and dysfunction in some connected neural circuits. However, the role of white matter (WM) in AN patients has rarely been investigated. The present study aimed to assess alterations in WM microstructure of the entire brain in females with AN using a voxel-based method on diffusion tensor imaging (DTI) data.Materials and methods: The study enrolled 8 female patients with AN and 14 age-matched females as controls (CW). The DTI data was collected from each subject to calculate the fractional anisotropy (FA) maps of the whole brain by the DTI-Studio software. Subsequently, a 2-sample t-test (P<0.05, corrected) was performed to detect the difference in FA maps of AN and CW group, and a Pearson’s correlation analyzed the relationship between mean FA value of brain regions and body mass index (BMI).Results: Compared with CW, AN patients revealed a significant decrease in FA maps in the left superior frontal gyrus, medial frontal gyrus, anterior cingulate cortex, middle frontal gyrus, inferior frontal gyrus, thalamus, and bilateral insula. Moreover, significantly positive correlations were established between the mean FA value of the left inferior frontal gyrus, insula as well as thalamus and BMI in AN patients.Conclusions: Our findings supported the presence of WM abnormality in patients with AN. The significant differences of FA maps, in patients with AN, were associated with their aberrant BMI. The results further improved our understanding of the pathophysiological mechanisms underlying AN. Keywords: anorexia nervosa, magnetic resonance imaging, diffusion tensor imaging, white matter
format	article
author	Hu SH Feng H Xu TT Zhang HR Zhao ZY Lai JB Xu DR Xu Y
author_facet	Hu SH Feng H Xu TT Zhang HR Zhao ZY Lai JB Xu DR Xu Y
author_sort	Hu SH
title	Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
title_short	Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
title_full	Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
title_fullStr	Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
title_full_unstemmed	Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
title_sort	altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f7e94a93793048abb895af0e247aa3fa
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Altered microstructure of brain white matter in females with anorexia nervosa: a diffusion tensor imaging study

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