The course of bipolar disorder in pregnant versus non-pregnant women

Abstract Background and rationale Although it has been suggested that pregnancy may influence the course of bipolar disorder (BD), studies show contradictory results. Until now, no studies included a finegrained validated method to report mood symptoms on a daily basis, such as the lifechart method...

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Autores principales:	Anja W. M. M. Stevens, Stasja Draisma, Peter J. J. Goossens, Birit F. P. Broekman, Adriaan Honig, Elise A. M. Knoppert-van der Klein, Willem A. Nolen, Robert M. Post, R. W. Kupka
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Bipolar disorder Course Pregnancy Life chart method Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/f7e979deab6341208f1348df783d332f
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spelling	oai:doaj.org-article:f7e979deab6341208f1348df783d332f2021-11-08T10:44:19ZThe course of bipolar disorder in pregnant versus non-pregnant women10.1186/s40345-021-00239-z2194-7511https://doaj.org/article/f7e979deab6341208f1348df783d332f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s40345-021-00239-zhttps://doaj.org/toc/2194-7511Abstract Background and rationale Although it has been suggested that pregnancy may influence the course of bipolar disorder (BD), studies show contradictory results. Until now, no studies included a finegrained validated method to report mood symptoms on a daily basis, such as the lifechart method (LCM). The aim of the present study is to investigate the course of BD during pregnancy by comparing LCM scores of pregnant and non-pregnant women. Methods Study design: Comparison of LCM scores of two prospective observational BD cohort studies, a cohort of pregnant women (n = 34) and a cohort of non-pregnant women of childbearing age (n = 52). Main study parameters are: (1) proportions of symptomatic and non-symptomatic days; (2) symptom severity, frequency, and duration of episodes; (3) state sequences, longitudinal variation of symptom severity scores. Results No differences in clinical course variables (symptomatic days, average severity scores, frequency, and duration of episodes in BD were found between pregnant and non-pregnant women. With a combination of State Sequence Analysis (SSA) and cluster analysis on the sequences of daily mood scores three comparable clusters were found in both samples: euthymic, moderately ill and severely ill. The distribution differences between pregnant and non-pregnant women were significant, with a majority of the pregnant women (68%) belonging to the moderately ill cluster and a majority of the non-pregnant women (46%) to the euthymic cluster. In pregnant women the average daily variation in mood symptoms as assessed with Shannon’s entropy was less than in non-pregnant women (respectively 0.43 versus 0.56). Conclusions Although the use of daily mood scores revealed no difference in overall course of BD in pregnant versus non-pregnant women, more pregnant than non-pregnant women belonged to the moderately ill cluster, and during pregnancy the variation in mood state was less than in non-pregnant women. Further research is necessary to clarify these findings.Anja W. M. M. StevensStasja DraismaPeter J. J. GoossensBirit F. P. BroekmanAdriaan HonigElise A. M. Knoppert-van der KleinWillem A. NolenRobert M. PostR. W. KupkaSpringerOpenarticleBipolar disorderCoursePregnancyLife chart methodNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurophysiology and neuropsychologyQP351-495ENInternational Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bipolar disorder Course Pregnancy Life chart method Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Bipolar disorder Course Pregnancy Life chart method Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurophysiology and neuropsychology QP351-495 Anja W. M. M. Stevens Stasja Draisma Peter J. J. Goossens Birit F. P. Broekman Adriaan Honig Elise A. M. Knoppert-van der Klein Willem A. Nolen Robert M. Post R. W. Kupka The course of bipolar disorder in pregnant versus non-pregnant women
description	Abstract Background and rationale Although it has been suggested that pregnancy may influence the course of bipolar disorder (BD), studies show contradictory results. Until now, no studies included a finegrained validated method to report mood symptoms on a daily basis, such as the lifechart method (LCM). The aim of the present study is to investigate the course of BD during pregnancy by comparing LCM scores of pregnant and non-pregnant women. Methods Study design: Comparison of LCM scores of two prospective observational BD cohort studies, a cohort of pregnant women (n = 34) and a cohort of non-pregnant women of childbearing age (n = 52). Main study parameters are: (1) proportions of symptomatic and non-symptomatic days; (2) symptom severity, frequency, and duration of episodes; (3) state sequences, longitudinal variation of symptom severity scores. Results No differences in clinical course variables (symptomatic days, average severity scores, frequency, and duration of episodes in BD were found between pregnant and non-pregnant women. With a combination of State Sequence Analysis (SSA) and cluster analysis on the sequences of daily mood scores three comparable clusters were found in both samples: euthymic, moderately ill and severely ill. The distribution differences between pregnant and non-pregnant women were significant, with a majority of the pregnant women (68%) belonging to the moderately ill cluster and a majority of the non-pregnant women (46%) to the euthymic cluster. In pregnant women the average daily variation in mood symptoms as assessed with Shannon’s entropy was less than in non-pregnant women (respectively 0.43 versus 0.56). Conclusions Although the use of daily mood scores revealed no difference in overall course of BD in pregnant versus non-pregnant women, more pregnant than non-pregnant women belonged to the moderately ill cluster, and during pregnancy the variation in mood state was less than in non-pregnant women. Further research is necessary to clarify these findings.
format	article
author	Anja W. M. M. Stevens Stasja Draisma Peter J. J. Goossens Birit F. P. Broekman Adriaan Honig Elise A. M. Knoppert-van der Klein Willem A. Nolen Robert M. Post R. W. Kupka
author_facet	Anja W. M. M. Stevens Stasja Draisma Peter J. J. Goossens Birit F. P. Broekman Adriaan Honig Elise A. M. Knoppert-van der Klein Willem A. Nolen Robert M. Post R. W. Kupka
author_sort	Anja W. M. M. Stevens
title	The course of bipolar disorder in pregnant versus non-pregnant women
title_short	The course of bipolar disorder in pregnant versus non-pregnant women
title_full	The course of bipolar disorder in pregnant versus non-pregnant women
title_fullStr	The course of bipolar disorder in pregnant versus non-pregnant women
title_full_unstemmed	The course of bipolar disorder in pregnant versus non-pregnant women
title_sort	course of bipolar disorder in pregnant versus non-pregnant women
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/f7e979deab6341208f1348df783d332f
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The course of bipolar disorder in pregnant versus non-pregnant women

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