Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients

Background: Neuroblastoma is a complex heterogeneous disease. Bone marrow is the most commonly affected metastatic site. The aim of the work: The current study aimed to assess the role of tyrosine hydroxylase in diagnosing bone marrow infiltration in neuroblastoma. Methods: Tyrosine hydroxylase was...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samar El-Shazly, Mona Abdellateif, Fadwa Said
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	neuroblastoma tyrosine hydroxylase bone marrow Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7e97f358b2a49149618648689520284
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7e97f358b2a49149618648689520284
record_format	dspace
spelling	oai:doaj.org-article:f7e97f358b2a491496186486895202842021-12-02T14:49:25ZTyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients2636-41742682-378010.21608/ijma.2021.70994.1292https://doaj.org/article/f7e97f358b2a491496186486895202842021-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_172330_77f1ddf07e6a3325cd87a9449d7afa82.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Neuroblastoma is a complex heterogeneous disease. Bone marrow is the most commonly affected metastatic site. The aim of the work: The current study aimed to assess the role of tyrosine hydroxylase in diagnosing bone marrow infiltration in neuroblastoma. Methods: Tyrosine hydroxylase was assessed in the bone marrow aspirate of 104 pediatric neuroblastoma patients, compared to 25 matched normal controls by real time polymerase chain reaction. The data were correlated to the clinic-pathological features of the patients, response to treatment, bone marrow infiltration, disease free survival and overall survival. Results: Tyrosine hydroxylase was expressed in 78/104 [75%] of the patients. Bone marrow infiltration was significantly higher in patients with high tyrosine hydroxylase expression compared to those with tyrosine hydroxylase low expression [median [range]: 193 [0-277750] versus 4 [0- 7849]; p=0.003]. Use of tyrosine hydroxylase for diagnosis of bone marrow involvement in neuroblastoma had a sensitivity of 55.2%, a specificity of 65.2%, and positive predictive value of 66.7% and negative predictive value of 53.6%. Conclusions: Tyrosine hydroxylase may serve as a useful tool for diagnosis of bone marrow infiltration in neuroblastoma. Bone marrow infiltration is associated with poor disease free survival and overall survival.Samar El-ShazlyMona AbdellateifFadwa SaidAl-Azhar University, Faculty of Medicine (Damietta)articleneuroblastomatyrosine hydroxylasebone marrowMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 3, Pp 1562-1569 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroblastoma tyrosine hydroxylase bone marrow Medicine (General) R5-920
spellingShingle	neuroblastoma tyrosine hydroxylase bone marrow Medicine (General) R5-920 Samar El-Shazly Mona Abdellateif Fadwa Said Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients
description	Background: Neuroblastoma is a complex heterogeneous disease. Bone marrow is the most commonly affected metastatic site. The aim of the work: The current study aimed to assess the role of tyrosine hydroxylase in diagnosing bone marrow infiltration in neuroblastoma. Methods: Tyrosine hydroxylase was assessed in the bone marrow aspirate of 104 pediatric neuroblastoma patients, compared to 25 matched normal controls by real time polymerase chain reaction. The data were correlated to the clinic-pathological features of the patients, response to treatment, bone marrow infiltration, disease free survival and overall survival. Results: Tyrosine hydroxylase was expressed in 78/104 [75%] of the patients. Bone marrow infiltration was significantly higher in patients with high tyrosine hydroxylase expression compared to those with tyrosine hydroxylase low expression [median [range]: 193 [0-277750] versus 4 [0- 7849]; p=0.003]. Use of tyrosine hydroxylase for diagnosis of bone marrow involvement in neuroblastoma had a sensitivity of 55.2%, a specificity of 65.2%, and positive predictive value of 66.7% and negative predictive value of 53.6%. Conclusions: Tyrosine hydroxylase may serve as a useful tool for diagnosis of bone marrow infiltration in neuroblastoma. Bone marrow infiltration is associated with poor disease free survival and overall survival.
format	article
author	Samar El-Shazly Mona Abdellateif Fadwa Said
author_facet	Samar El-Shazly Mona Abdellateif Fadwa Said
author_sort	Samar El-Shazly
title	Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients
title_short	Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients
title_full	Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients
title_fullStr	Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients
title_full_unstemmed	Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients
title_sort	tyrosine hydroxylase expression is associated with bone marrow infiltration in neuroblastoma patients
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/f7e97f358b2a49149618648689520284
work_keys_str_mv	AT samarelshazly tyrosinehydroxylaseexpressionisassociatedwithbonemarrowinfiltrationinneuroblastomapatients AT monaabdellateif tyrosinehydroxylaseexpressionisassociatedwithbonemarrowinfiltrationinneuroblastomapatients AT fadwasaid tyrosinehydroxylaseexpressionisassociatedwithbonemarrowinfiltrationinneuroblastomapatients
_version_	1718389486966013952

Tyrosine Hydroxylase Expression is Associated with Bone Marrow Infiltration in Neuroblastoma Patients

Ejemplares similares