Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin heavy chain locus and this is associated with poo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7edb1aa7e034097bfaeab285876053f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7edb1aa7e034097bfaeab285876053f
record_format	dspace
spelling	oai:doaj.org-article:f7edb1aa7e034097bfaeab285876053f2021-12-02T14:38:45ZMultiple myeloma immunoglobulin lambda translocations portend poor prognosis10.1038/s41467-019-09555-62041-1723https://doaj.org/article/f7edb1aa7e034097bfaeab285876053f2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09555-6https://doaj.org/toc/2041-1723Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin heavy chain locus and this is associated with poor prognosis.Benjamin G. BarwickPaola NeriNizar J. BahlisAjay K. NookaMadhav V. DhodapkarDavid L. JayeCraig C. HofmeisterJonathan L. KaufmanVikas A. GuptaDaniel AuclairJonathan J. KeatsSagar LonialPaula M. VertinoLawrence H. BoiseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin G. Barwick Paola Neri Nizar J. Bahlis Ajay K. Nooka Madhav V. Dhodapkar David L. Jaye Craig C. Hofmeister Jonathan L. Kaufman Vikas A. Gupta Daniel Auclair Jonathan J. Keats Sagar Lonial Paula M. Vertino Lawrence H. Boise Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
description	Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin heavy chain locus and this is associated with poor prognosis.
format	article
author	Benjamin G. Barwick Paola Neri Nizar J. Bahlis Ajay K. Nooka Madhav V. Dhodapkar David L. Jaye Craig C. Hofmeister Jonathan L. Kaufman Vikas A. Gupta Daniel Auclair Jonathan J. Keats Sagar Lonial Paula M. Vertino Lawrence H. Boise
author_facet	Benjamin G. Barwick Paola Neri Nizar J. Bahlis Ajay K. Nooka Madhav V. Dhodapkar David L. Jaye Craig C. Hofmeister Jonathan L. Kaufman Vikas A. Gupta Daniel Auclair Jonathan J. Keats Sagar Lonial Paula M. Vertino Lawrence H. Boise
author_sort	Benjamin G. Barwick
title	Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
title_short	Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
title_full	Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
title_fullStr	Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
title_full_unstemmed	Multiple myeloma immunoglobulin lambda translocations portend poor prognosis
title_sort	multiple myeloma immunoglobulin lambda translocations portend poor prognosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f7edb1aa7e034097bfaeab285876053f
work_keys_str_mv	AT benjamingbarwick multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT paolaneri multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT nizarjbahlis multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT ajayknooka multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT madhavvdhodapkar multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT davidljaye multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT craigchofmeister multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT jonathanlkaufman multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT vikasagupta multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT danielauclair multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT jonathanjkeats multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT sagarlonial multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT paulamvertino multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis AT lawrencehboise multiplemyelomaimmunoglobulinlambdatranslocationsportendpoorprognosis
_version_	1718390929964924928

Multiple myeloma immunoglobulin lambda translocations portend poor prognosis

Ejemplares similares