Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass

Abstract This study aims to compare sleeve gastrectomy (SG) and one anastomosis gastric bypass (OAGB) in terms of remission of type 2 diabetes mellitus (T2DM) in obese patients. All T2DM patients were followed-up for at least 36 months. The primary outcome was remission of T2DM. Secondary endpoints...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gavriella Zoi Vrakopoulou, Charalampos Theodoropoulos, Vasileios Kalles, George Zografos, Konstantinos Almpanopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7f0a89be7b4468ba3b2b47224e4f6d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7f0a89be7b4468ba3b2b47224e4f6d3
record_format	dspace
spelling	oai:doaj.org-article:f7f0a89be7b4468ba3b2b47224e4f6d32021-12-02T13:34:45ZType 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass10.1038/s41598-021-83807-82045-2322https://doaj.org/article/f7f0a89be7b4468ba3b2b47224e4f6d32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83807-8https://doaj.org/toc/2045-2322Abstract This study aims to compare sleeve gastrectomy (SG) and one anastomosis gastric bypass (OAGB) in terms of remission of type 2 diabetes mellitus (T2DM) in obese patients. All T2DM patients were followed-up for at least 36 months. The primary outcome was remission of T2DM. Secondary endpoints included weight reduction and the procedure’s impact on quality of life. In total, 53/1177 morbidly obese patients who underwent SG (Group A, n = 28) or OAGB (Group B, n = 25) had T2DM. Preoperatively, the mean Body Mass Index (BMI) values were 52.2 ± 8.5 kg/m2 and 52.9 ± 10.9 kg/m2 for Group A and Group B, respectively. Six patients in Group A were insulin dependent, while 8 were insulin dependent in Group B. After 36 months, diabetes remission was achieved by only 10 patients (35.7%) in Group A. However, in Group B, 22 patients (88%) remained off antidiabetic agents (p < 0.0001), with ΔHbA1c (%) reaching 1.4 ± 1.5% in Group A and 2.7 ± 2.1% in Group B (p = 0.02). Excess weight loss% (%EWL) was again significantly different between the two groups (MA = 79.8 ± 14.5%, MB = 93.3 ± 16.0%, p = 0.003). OAGB is more effective in improving glycaemic control and %EWL, with almost immediate resolution of diabetes, as well as long-term weight loss.Gavriella Zoi VrakopoulouCharalampos TheodoropoulosVasileios KallesGeorge ZografosKonstantinos AlmpanopoulosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gavriella Zoi Vrakopoulou Charalampos Theodoropoulos Vasileios Kalles George Zografos Konstantinos Almpanopoulos Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
description	Abstract This study aims to compare sleeve gastrectomy (SG) and one anastomosis gastric bypass (OAGB) in terms of remission of type 2 diabetes mellitus (T2DM) in obese patients. All T2DM patients were followed-up for at least 36 months. The primary outcome was remission of T2DM. Secondary endpoints included weight reduction and the procedure’s impact on quality of life. In total, 53/1177 morbidly obese patients who underwent SG (Group A, n = 28) or OAGB (Group B, n = 25) had T2DM. Preoperatively, the mean Body Mass Index (BMI) values were 52.2 ± 8.5 kg/m2 and 52.9 ± 10.9 kg/m2 for Group A and Group B, respectively. Six patients in Group A were insulin dependent, while 8 were insulin dependent in Group B. After 36 months, diabetes remission was achieved by only 10 patients (35.7%) in Group A. However, in Group B, 22 patients (88%) remained off antidiabetic agents (p < 0.0001), with ΔHbA1c (%) reaching 1.4 ± 1.5% in Group A and 2.7 ± 2.1% in Group B (p = 0.02). Excess weight loss% (%EWL) was again significantly different between the two groups (MA = 79.8 ± 14.5%, MB = 93.3 ± 16.0%, p = 0.003). OAGB is more effective in improving glycaemic control and %EWL, with almost immediate resolution of diabetes, as well as long-term weight loss.
format	article
author	Gavriella Zoi Vrakopoulou Charalampos Theodoropoulos Vasileios Kalles George Zografos Konstantinos Almpanopoulos
author_facet	Gavriella Zoi Vrakopoulou Charalampos Theodoropoulos Vasileios Kalles George Zografos Konstantinos Almpanopoulos
author_sort	Gavriella Zoi Vrakopoulou
title	Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
title_short	Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
title_full	Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
title_fullStr	Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
title_full_unstemmed	Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
title_sort	type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7f0a89be7b4468ba3b2b47224e4f6d3
work_keys_str_mv	AT gavriellazoivrakopoulou type2diabetesmellitusstatusinobesepatientsfollowingsleevegastrectomyoroneanastomosisgastricbypass AT charalampostheodoropoulos type2diabetesmellitusstatusinobesepatientsfollowingsleevegastrectomyoroneanastomosisgastricbypass AT vasileioskalles type2diabetesmellitusstatusinobesepatientsfollowingsleevegastrectomyoroneanastomosisgastricbypass AT georgezografos type2diabetesmellitusstatusinobesepatientsfollowingsleevegastrectomyoroneanastomosisgastricbypass AT konstantinosalmpanopoulos type2diabetesmellitusstatusinobesepatientsfollowingsleevegastrectomyoroneanastomosisgastricbypass
_version_	1718392772422008832

Type 2 diabetes mellitus status in obese patients following sleeve gastrectomy or one anastomosis gastric bypass

Ejemplares similares