HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.
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Nature Portfolio
2020
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oai:doaj.org-article:f7f1aa4b6fd944ee94c69c85f704d1782021-12-02T14:58:51ZHOX13-dependent chromatin accessibility underlies the transition towards the digit development program10.1038/s41467-020-16317-22041-1723https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d1782020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16317-2https://doaj.org/toc/2041-1723Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.Ines DesanlisYacine KherdjemilAlexandre MayranYasser BouklouchClaudia GentileRushikesh ShethRolf ZellerJacques DrouinMarie KmitaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
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Science Q Ines Desanlis Yacine Kherdjemil Alexandre Mayran Yasser Bouklouch Claudia Gentile Rushikesh Sheth Rolf Zeller Jacques Drouin Marie Kmita HOX13-dependent chromatin accessibility underlies the transition towards the digit development program |
description |
Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program. |
format |
article |
author |
Ines Desanlis Yacine Kherdjemil Alexandre Mayran Yasser Bouklouch Claudia Gentile Rushikesh Sheth Rolf Zeller Jacques Drouin Marie Kmita |
author_facet |
Ines Desanlis Yacine Kherdjemil Alexandre Mayran Yasser Bouklouch Claudia Gentile Rushikesh Sheth Rolf Zeller Jacques Drouin Marie Kmita |
author_sort |
Ines Desanlis |
title |
HOX13-dependent chromatin accessibility underlies the transition towards the digit development program |
title_short |
HOX13-dependent chromatin accessibility underlies the transition towards the digit development program |
title_full |
HOX13-dependent chromatin accessibility underlies the transition towards the digit development program |
title_fullStr |
HOX13-dependent chromatin accessibility underlies the transition towards the digit development program |
title_full_unstemmed |
HOX13-dependent chromatin accessibility underlies the transition towards the digit development program |
title_sort |
hox13-dependent chromatin accessibility underlies the transition towards the digit development program |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d178 |
work_keys_str_mv |
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_version_ |
1718389300764082176 |