HOX13-dependent chromatin accessibility underlies the transition towards the digit development program

Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.

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Autores principales: Ines Desanlis, Yacine Kherdjemil, Alexandre Mayran, Yasser Bouklouch, Claudia Gentile, Rushikesh Sheth, Rolf Zeller, Jacques Drouin, Marie Kmita
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d178
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spelling oai:doaj.org-article:f7f1aa4b6fd944ee94c69c85f704d1782021-12-02T14:58:51ZHOX13-dependent chromatin accessibility underlies the transition towards the digit development program10.1038/s41467-020-16317-22041-1723https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d1782020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16317-2https://doaj.org/toc/2041-1723Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.Ines DesanlisYacine KherdjemilAlexandre MayranYasser BouklouchClaudia GentileRushikesh ShethRolf ZellerJacques DrouinMarie KmitaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ines Desanlis
Yacine Kherdjemil
Alexandre Mayran
Yasser Bouklouch
Claudia Gentile
Rushikesh Sheth
Rolf Zeller
Jacques Drouin
Marie Kmita
HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
description Pioneer factors direct cell fate through switching inaccessible chromatin to an accessible state at specific target enhancers. Here the authors show that HOX13 transcription factors have a pioneer activity which is required for the proper implementation of the distal limb developmental program.
format article
author Ines Desanlis
Yacine Kherdjemil
Alexandre Mayran
Yasser Bouklouch
Claudia Gentile
Rushikesh Sheth
Rolf Zeller
Jacques Drouin
Marie Kmita
author_facet Ines Desanlis
Yacine Kherdjemil
Alexandre Mayran
Yasser Bouklouch
Claudia Gentile
Rushikesh Sheth
Rolf Zeller
Jacques Drouin
Marie Kmita
author_sort Ines Desanlis
title HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
title_short HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
title_full HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
title_fullStr HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
title_full_unstemmed HOX13-dependent chromatin accessibility underlies the transition towards the digit development program
title_sort hox13-dependent chromatin accessibility underlies the transition towards the digit development program
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f7f1aa4b6fd944ee94c69c85f704d178
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