Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles

Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles

Gopinath Devanand Venkatasubbu,1 S Ramasamy,2 Pramod Reddy Gaddam,3 J Kumar2 1Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India; 2Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India; 3Department of Pharmacology, Siddha Central Research Institute, Chennai,...

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Autores principales: Venkatasubbu GD, Ramasamy S, Gaddam PR, Kumar J
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/f7f36e3facf249cc883954fd23586f59
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spelling oai:doaj.org-article:f7f36e3facf249cc883954fd23586f592021-12-02T05:14:27ZAcute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles1178-2013https://doaj.org/article/f7f36e3facf249cc883954fd23586f592015-10-01T00:00:00Zhttps://www.dovepress.com/acute-and-subchronic-toxicity-analysis-of-surface-modified-paclitaxel--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gopinath Devanand Venkatasubbu,1 S Ramasamy,2 Pramod Reddy Gaddam,3 J Kumar2 1Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India; 2Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India; 3Department of Pharmacology, Siddha Central Research Institute, Chennai, Tamil Nadu, India Abstract: Nanoparticles are widely used for targeted drug delivery applications. Surface modification with appropriate polymer and ligands is carried out to target the drug to the affected area. Toxicity analysis is carried out to evaluate the safety of the surface modified nanoparticles. In this study, paclitaxel attached, folic acid functionalized, polyethylene glycol modified hydroxyapatite and titanium dioxide nanoparticles were used for targeted drug delivery system. The toxicological behavior of the system was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical, hematological, and histopathological analysis was also done. There were no significant alterations in the biochemical parameters at a low dosage. There was a small change in alkaline phosphatase (ALP) level at a high dosage. The results indicate a safe toxicological profile. Keywords: acute and subchronic toxicology, hematological analysis, biochemical analysis, histopathologyVenkatasubbu GDRamasamy SGaddam PRKumar JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Supplement 1 Challenges in biomaterials research, Pp 137-148 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Venkatasubbu GD
Ramasamy S
Gaddam PR
Kumar J
Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
description Gopinath Devanand Venkatasubbu,1 S Ramasamy,2 Pramod Reddy Gaddam,3 J Kumar2 1Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India; 2Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India; 3Department of Pharmacology, Siddha Central Research Institute, Chennai, Tamil Nadu, India Abstract: Nanoparticles are widely used for targeted drug delivery applications. Surface modification with appropriate polymer and ligands is carried out to target the drug to the affected area. Toxicity analysis is carried out to evaluate the safety of the surface modified nanoparticles. In this study, paclitaxel attached, folic acid functionalized, polyethylene glycol modified hydroxyapatite and titanium dioxide nanoparticles were used for targeted drug delivery system. The toxicological behavior of the system was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical, hematological, and histopathological analysis was also done. There were no significant alterations in the biochemical parameters at a low dosage. There was a small change in alkaline phosphatase (ALP) level at a high dosage. The results indicate a safe toxicological profile. Keywords: acute and subchronic toxicology, hematological analysis, biochemical analysis, histopathology
format article
author Venkatasubbu GD
Ramasamy S
Gaddam PR
Kumar J
author_facet Venkatasubbu GD
Ramasamy S
Gaddam PR
Kumar J
author_sort Venkatasubbu GD
title Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
title_short Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
title_full Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
title_fullStr Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
title_full_unstemmed Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
title_sort acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/f7f36e3facf249cc883954fd23586f59
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AT ramasamys acuteandsubchronictoxicityanalysisofsurfacemodifiedpaclitaxelattachedhydroxyapatiteandnbsptitaniumdioxidenanoparticles
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