Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.

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Autores principales:	Wei Zhang, Tianjiao Ji, Yang Li, Yueqin Zheng, Manisha Mehta, Chao Zhao, Andong Liu, Daniel S. Kohane
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7f5610bdcbc4f8d89c158cdd6ef884d
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spelling	oai:doaj.org-article:f7f5610bdcbc4f8d89c158cdd6ef884d2021-12-02T14:41:24ZLight-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia10.1038/s41467-020-16177-w2041-1723https://doaj.org/article/f7f5610bdcbc4f8d89c158cdd6ef884d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16177-whttps://doaj.org/toc/2041-1723Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.Wei ZhangTianjiao JiYang LiYueqin ZhengManisha MehtaChao ZhaoAndong LiuDaniel S. KohaneNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Zhang Tianjiao Ji Yang Li Yueqin Zheng Manisha Mehta Chao Zhao Andong Liu Daniel S. Kohane Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
description	Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.
format	article
author	Wei Zhang Tianjiao Ji Yang Li Yueqin Zheng Manisha Mehta Chao Zhao Andong Liu Daniel S. Kohane
author_facet	Wei Zhang Tianjiao Ji Yang Li Yueqin Zheng Manisha Mehta Chao Zhao Andong Liu Daniel S. Kohane
author_sort	Wei Zhang
title	Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
title_short	Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
title_full	Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
title_fullStr	Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
title_full_unstemmed	Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
title_sort	light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f7f5610bdcbc4f8d89c158cdd6ef884d
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Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

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