Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Local anesthetic sustained release systems suffer from untriggered rapid drug release upon application. Here the authors overcome this issue by covalently linking tetracaine to a polymer gel via a photo-cleavable linkage, enabling light-triggered and repeatable drug release.

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Bibliographic Details
Main Authors: Wei Zhang, Tianjiao Ji, Yang Li, Yueqin Zheng, Manisha Mehta, Chao Zhao, Andong Liu, Daniel S. Kohane
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Q
Online Access:https://doaj.org/article/f7f5610bdcbc4f8d89c158cdd6ef884d
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