Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

Peidang Liu,1,2 Haizhen Jin,1 Zhirui Guo,3 Jun Ma,4 Jing Zhao,1 Dongdong Li,1 Hao Wu,2 Ning Gu2 1School of Medicine, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 3The Second Affiliated Hospital of Nanjing Medical University, 4Tr...

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Autores principales:	Liu PD, Jin H, Guo Z, Ma J, Zhao J, Li D, Wu H, Gu N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Gold nanoparticles silver nanoparticles radiosensitization glioma apoptosis autophagy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7f57ff6797542bd804ac5022737f6b3
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spelling	oai:doaj.org-article:f7f57ff6797542bd804ac5022737f6b32021-12-02T07:21:41ZSilver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma1178-2013https://doaj.org/article/f7f57ff6797542bd804ac5022737f6b32016-10-01T00:00:00Zhttps://www.dovepress.com/silver-nanoparticles-outperform-gold-nanoparticles-in-radiosensitizing-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Peidang Liu,1,2 Haizhen Jin,1 Zhirui Guo,3 Jun Ma,4 Jing Zhao,1 Dongdong Li,1 Hao Wu,2 Ning Gu2 1School of Medicine, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 3The Second Affiliated Hospital of Nanjing Medical University, 4Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, People’s Republic of China Abstract: Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma. Keywords: gold nanoparticles, silver nanoparticles, radiosensitization, glioma, apoptosis, autophagyLiu PDJin HGuo ZMa JZhao JLi DWu HGu NDove Medical PressarticleGold nanoparticlessilver nanoparticlesradiosensitizationgliomaapoptosisautophagyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 5003-5014 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold nanoparticles silver nanoparticles radiosensitization glioma apoptosis autophagy Medicine (General) R5-920
spellingShingle	Gold nanoparticles silver nanoparticles radiosensitization glioma apoptosis autophagy Medicine (General) R5-920 Liu PD Jin H Guo Z Ma J Zhao J Li D Wu H Gu N Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
description	Peidang Liu,1,2 Haizhen Jin,1 Zhirui Guo,3 Jun Ma,4 Jing Zhao,1 Dongdong Li,1 Hao Wu,2 Ning Gu2 1School of Medicine, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, 3The Second Affiliated Hospital of Nanjing Medical University, 4Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing, People’s Republic of China Abstract: Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma. Keywords: gold nanoparticles, silver nanoparticles, radiosensitization, glioma, apoptosis, autophagy
format	article
author	Liu PD Jin H Guo Z Ma J Zhao J Li D Wu H Gu N
author_facet	Liu PD Jin H Guo Z Ma J Zhao J Li D Wu H Gu N
author_sort	Liu PD
title	Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
title_short	Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
title_full	Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
title_fullStr	Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
title_full_unstemmed	Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
title_sort	silver nanoparticles outperform gold nanoparticles in radiosensitizing u251 cells in vitro and in an intracranial mouse model of glioma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/f7f57ff6797542bd804ac5022737f6b3
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Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

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