Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study

Brain dopamine signaling is essential for the motivation to eat, and obesity is associated with altered dopaminergic signaling and increased food craving. We used molecular neuroimaging to explore whether striatal dopamine transporter (DAT) availability is associated with craving as measured with th...

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Autores principales:	Jamie van Son, Katy A. van Galen, Anne Marijn Bruijn, Karin E. Koopman, Ruth I. Versteeg, Susanne E. la Fleur, Mireille J. Serlie, Jan Booij
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	food craving obesity dopamine transporter SPECT Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f7f5e20f63874c798c4de457e279e23b
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spelling	oai:doaj.org-article:f7f5e20f63874c798c4de457e279e23b2021-11-25T16:56:58ZStriatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study10.3390/brainsci111114282076-3425https://doaj.org/article/f7f5e20f63874c798c4de457e279e23b2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1428https://doaj.org/toc/2076-3425Brain dopamine signaling is essential for the motivation to eat, and obesity is associated with altered dopaminergic signaling and increased food craving. We used molecular neuroimaging to explore whether striatal dopamine transporter (DAT) availability is associated with craving as measured with the General Food Craving Questionnaire-Trait (G-FCQ-T). We here show that humans with obesity (<i>n</i> = 34) experienced significantly more craving for food compared with lean subjects (<i>n</i> = 32), but food craving did not correlate significantly with striatal DAT availability as assessed with <sup>123</sup>I-FP-CIT single-photon emission computed tomography. We conclude that food craving is increased in obesity, but the scores for food craving are not related to changes in striatal DAT availability.Jamie van SonKaty A. van GalenAnne Marijn BruijnKarin E. KoopmanRuth I. VersteegSusanne E. la FleurMireille J. SerlieJan BooijMDPI AGarticlefood cravingobesitydopamine transporterSPECTNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1428, p 1428 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	food craving obesity dopamine transporter SPECT Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	food craving obesity dopamine transporter SPECT Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jamie van Son Katy A. van Galen Anne Marijn Bruijn Karin E. Koopman Ruth I. Versteeg Susanne E. la Fleur Mireille J. Serlie Jan Booij Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study
description	Brain dopamine signaling is essential for the motivation to eat, and obesity is associated with altered dopaminergic signaling and increased food craving. We used molecular neuroimaging to explore whether striatal dopamine transporter (DAT) availability is associated with craving as measured with the General Food Craving Questionnaire-Trait (G-FCQ-T). We here show that humans with obesity (<i>n</i> = 34) experienced significantly more craving for food compared with lean subjects (<i>n</i> = 32), but food craving did not correlate significantly with striatal DAT availability as assessed with <sup>123</sup>I-FP-CIT single-photon emission computed tomography. We conclude that food craving is increased in obesity, but the scores for food craving are not related to changes in striatal DAT availability.
format	article
author	Jamie van Son Katy A. van Galen Anne Marijn Bruijn Karin E. Koopman Ruth I. Versteeg Susanne E. la Fleur Mireille J. Serlie Jan Booij
author_facet	Jamie van Son Katy A. van Galen Anne Marijn Bruijn Karin E. Koopman Ruth I. Versteeg Susanne E. la Fleur Mireille J. Serlie Jan Booij
author_sort	Jamie van Son
title	Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study
title_short	Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study
title_full	Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study
title_fullStr	Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study
title_full_unstemmed	Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study
title_sort	striatal dopamine transporter availability is not associated with food craving in lean and obese humans; a molecular imaging study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f7f5e20f63874c798c4de457e279e23b
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Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study

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