The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery
BACKGROUND AND OBJECTIVE: Intraoperative bleeding during endoscopic sinus surgery compromises the surgeon s vision for surgery at the surgical field. Since tizanidine causes contraction of peripheral blood vessels and hypotension, which together reduce blood flow to nasal mucosa, this study was perf...
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Babol University of Medical Sciences
2020
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oai:doaj.org-article:f7f650384ad34641b3e87abfd60f21a12021-11-09T10:15:54ZThe Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery1561-41072251-7170https://doaj.org/article/f7f650384ad34641b3e87abfd60f21a12020-03-01T00:00:00Zhttp://jbums.org/article-1-8791-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Intraoperative bleeding during endoscopic sinus surgery compromises the surgeon s vision for surgery at the surgical field. Since tizanidine causes contraction of peripheral blood vessels and hypotension, which together reduce blood flow to nasal mucosa, this study was performed to evaluate the effect of oral tizanidine on the quality of vision at the surgical field during endoscopic sinus surgery. METHODS: This double-blind clinical study was performed on 60 patients. Patients were randomly divided into two groups by computer randomization software (2.0) and received 6 mg tizanidine and placebo before the surgery. During the operation, the quality of the operation field was evaluated and scored by the surgeon based on Boezaart scale. Pain score in recovery and 6 hours after surgery and intraoperative hemodynamic parameters were assessed. FINDINGS: The quality of the surgical field based on the Boezaart scale was significantly better in the group receiving tizanidine (p=0.04). Pain score in recovery was 2.83±1.17 in the case group and 4.53±1.56 in the control group (p=0.001). Pain score 6 hours after surgery in the case group was 3.23±1.22 and in the control group was 4.13±1.33 (p=0.008). Mean arterial blood pressure (p=0.03) and heart rate (p=0.19) during surgery were lower in the tizanidine group. CONCLUSION: The results of the study showed that tizanidine as a perioperative medication before endoscopic sinus surgery improves the quality of vision at the surgical field and provides a better hemodynamic profile for patients.A MahooriB GholamveisiM GolmohammadiSh Pashaei KhoeiSh SaneBabol University of Medical Sciencesarticletizanidineendoscopic sinus surgerybleedingarterial pressure.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 181-187 (2020) |
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DOAJ |
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EN FA |
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tizanidine endoscopic sinus surgery bleeding arterial pressure. Medicine R Medicine (General) R5-920 |
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tizanidine endoscopic sinus surgery bleeding arterial pressure. Medicine R Medicine (General) R5-920 A Mahoori B Gholamveisi M Golmohammadi Sh Pashaei Khoei Sh Sane The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| description |
BACKGROUND AND OBJECTIVE: Intraoperative bleeding during endoscopic sinus surgery compromises the surgeon s vision for surgery at the surgical field. Since tizanidine causes contraction of peripheral blood vessels and hypotension, which together reduce blood flow to nasal mucosa, this study was performed to evaluate the effect of oral tizanidine on the quality of vision at the surgical field during endoscopic sinus surgery.
METHODS: This double-blind clinical study was performed on 60 patients. Patients were randomly divided into two groups by computer randomization software (2.0) and received 6 mg tizanidine and placebo before the surgery. During the operation, the quality of the operation field was evaluated and scored by the surgeon based on Boezaart scale. Pain score in recovery and 6 hours after surgery and intraoperative hemodynamic parameters were assessed.
FINDINGS: The quality of the surgical field based on the Boezaart scale was significantly better in the group receiving tizanidine (p=0.04). Pain score in recovery was 2.83±1.17 in the case group and 4.53±1.56 in the control group (p=0.001). Pain score 6 hours after surgery in the case group was 3.23±1.22 and in the control group was 4.13±1.33 (p=0.008). Mean arterial blood pressure (p=0.03) and heart rate (p=0.19) during surgery were lower in the tizanidine group.
CONCLUSION: The results of the study showed that tizanidine as a perioperative medication before endoscopic sinus surgery improves the quality of vision at the surgical field and provides a better hemodynamic profile for patients. |
| format |
article |
| author |
A Mahoori B Gholamveisi M Golmohammadi Sh Pashaei Khoei Sh Sane |
| author_facet |
A Mahoori B Gholamveisi M Golmohammadi Sh Pashaei Khoei Sh Sane |
| author_sort |
A Mahoori |
| title |
The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_short |
The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_full |
The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_fullStr |
The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_full_unstemmed |
The Effect of Oral Tizanidine on Bleeding and Quality of Surgical Field During Endoscopic Sinus Surgery |
| title_sort |
effect of oral tizanidine on bleeding and quality of surgical field during endoscopic sinus surgery |
| publisher |
Babol University of Medical Sciences |
| publishDate |
2020 |
| url |
https://doaj.org/article/f7f650384ad34641b3e87abfd60f21a1 |
| work_keys_str_mv |
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