Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
SuFu is a tumour suppressor in medulloblastoma and regulates Gli proteins in the Sonic Hedgehog pathway; however, the molecular mechanisms behind this regulation are unclear. Here, the authors show that the Itch/β-arrestin2 complex binds and ubiquitylates SuFu, facilitating the interaction with Gli3...
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2018
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oai:doaj.org-article:f7f69de80acf45bbb0fc69f6b60924c12021-12-02T16:49:19ZItch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis10.1038/s41467-018-03339-02041-1723https://doaj.org/article/f7f69de80acf45bbb0fc69f6b60924c12018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03339-0https://doaj.org/toc/2041-1723SuFu is a tumour suppressor in medulloblastoma and regulates Gli proteins in the Sonic Hedgehog pathway; however, the molecular mechanisms behind this regulation are unclear. Here, the authors show that the Itch/β-arrestin2 complex binds and ubiquitylates SuFu, facilitating the interaction with Gli3 and its conversion into the repressive form, thus counteracting medulloblastoma formation.Paola InfanteRoberta FaeddaFlavia BernardiFrancesca BufalieriLudovica Lospinoso SeveriniRomina AlfonsiDaniela MazzàMariangela SilerSonia ConiAgnese PoMarialaura PetroniElisabetta FerrettiMattia MoriEnrico De SmaeleGianluca CanettieriCarlo CapalboMarella MaroderIsabella ScrepantiMarcel KoolStefan M. PfisterDaniele GuardavaccaroAlberto GulinoLucia Di MarcotullioNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
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Science Q Paola Infante Roberta Faedda Flavia Bernardi Francesca Bufalieri Ludovica Lospinoso Severini Romina Alfonsi Daniela Mazzà Mariangela Siler Sonia Coni Agnese Po Marialaura Petroni Elisabetta Ferretti Mattia Mori Enrico De Smaele Gianluca Canettieri Carlo Capalbo Marella Maroder Isabella Screpanti Marcel Kool Stefan M. Pfister Daniele Guardavaccaro Alberto Gulino Lucia Di Marcotullio Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis |
| description |
SuFu is a tumour suppressor in medulloblastoma and regulates Gli proteins in the Sonic Hedgehog pathway; however, the molecular mechanisms behind this regulation are unclear. Here, the authors show that the Itch/β-arrestin2 complex binds and ubiquitylates SuFu, facilitating the interaction with Gli3 and its conversion into the repressive form, thus counteracting medulloblastoma formation. |
| format |
article |
| author |
Paola Infante Roberta Faedda Flavia Bernardi Francesca Bufalieri Ludovica Lospinoso Severini Romina Alfonsi Daniela Mazzà Mariangela Siler Sonia Coni Agnese Po Marialaura Petroni Elisabetta Ferretti Mattia Mori Enrico De Smaele Gianluca Canettieri Carlo Capalbo Marella Maroder Isabella Screpanti Marcel Kool Stefan M. Pfister Daniele Guardavaccaro Alberto Gulino Lucia Di Marcotullio |
| author_facet |
Paola Infante Roberta Faedda Flavia Bernardi Francesca Bufalieri Ludovica Lospinoso Severini Romina Alfonsi Daniela Mazzà Mariangela Siler Sonia Coni Agnese Po Marialaura Petroni Elisabetta Ferretti Mattia Mori Enrico De Smaele Gianluca Canettieri Carlo Capalbo Marella Maroder Isabella Screpanti Marcel Kool Stefan M. Pfister Daniele Guardavaccaro Alberto Gulino Lucia Di Marcotullio |
| author_sort |
Paola Infante |
| title |
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis |
| title_short |
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis |
| title_full |
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis |
| title_fullStr |
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis |
| title_full_unstemmed |
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis |
| title_sort |
itch/β-arrestin2-dependent non-proteolytic ubiquitylation of sufu controls hedgehog signalling and medulloblastoma tumorigenesis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/f7f69de80acf45bbb0fc69f6b60924c1 |
| work_keys_str_mv |
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