Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes

Abstract We investigated the association between the incidence of severe hypoglycemia and the risk of end-stage renal disease (ESRD) in patients with type 2 diabetes. Baseline and follow-up data for 988,333 participants with type 2 diabetes were retrieved from the National Health Insurance System da...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Hyung-Wook Kim, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7f7f33cf952497d930d25d83b50e5ef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7f7f33cf952497d930d25d83b50e5ef
record_format	dspace
spelling	oai:doaj.org-article:f7f7f33cf952497d930d25d83b50e5ef2021-12-02T11:02:38ZSevere hypoglycemia and the risk of end stage renal disease in type 2 diabetes10.1038/s41598-021-82838-52045-2322https://doaj.org/article/f7f7f33cf952497d930d25d83b50e5ef2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82838-5https://doaj.org/toc/2045-2322Abstract We investigated the association between the incidence of severe hypoglycemia and the risk of end-stage renal disease (ESRD) in patients with type 2 diabetes. Baseline and follow-up data for 988,333 participants with type 2 diabetes were retrieved from the National Health Insurance System database. The number of severe hypoglycemia episodes experienced from 2007 to 2009 was determined. The primary outcome was the development of ESRD after the baseline evaluation. Participants were followed from the baseline until death or December 31, 2016, during this period 14,545 participants (1.5%) developed ESRD. In the crude model, compared with those who experienced no severe hypoglycemia, the hazard ratios (95% confidential intervals) for developing ESRD were 4.96 (4.57–5.39), 6.84 (5.62–8.32), and 9.51 (7.14–12.66) in participants who experienced one, two, and three or more episodes of severe hypoglycemia, respectively. Further adjustment for various confounding factors attenuated the association between severe hypoglycemia and ESRD; the significance of the association between severe hypoglycemia and ESRD was maintained. Having three or more severe hypoglycemia episodes was associated with a nearly two-fold increased risk of developing ESRD. Prior episodes of severe hypoglycemia were associated with an increased risk of ESRD among Korean adults with type 2 diabetes.Jae-Seung YunYong-Moon ParkKyungdo HanHyung-Wook KimSeon-Ah ChaYu-Bae AhnSeung-Hyun KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae-Seung Yun Yong-Moon Park Kyungdo Han Hyung-Wook Kim Seon-Ah Cha Yu-Bae Ahn Seung-Hyun Ko Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
description	Abstract We investigated the association between the incidence of severe hypoglycemia and the risk of end-stage renal disease (ESRD) in patients with type 2 diabetes. Baseline and follow-up data for 988,333 participants with type 2 diabetes were retrieved from the National Health Insurance System database. The number of severe hypoglycemia episodes experienced from 2007 to 2009 was determined. The primary outcome was the development of ESRD after the baseline evaluation. Participants were followed from the baseline until death or December 31, 2016, during this period 14,545 participants (1.5%) developed ESRD. In the crude model, compared with those who experienced no severe hypoglycemia, the hazard ratios (95% confidential intervals) for developing ESRD were 4.96 (4.57–5.39), 6.84 (5.62–8.32), and 9.51 (7.14–12.66) in participants who experienced one, two, and three or more episodes of severe hypoglycemia, respectively. Further adjustment for various confounding factors attenuated the association between severe hypoglycemia and ESRD; the significance of the association between severe hypoglycemia and ESRD was maintained. Having three or more severe hypoglycemia episodes was associated with a nearly two-fold increased risk of developing ESRD. Prior episodes of severe hypoglycemia were associated with an increased risk of ESRD among Korean adults with type 2 diabetes.
format	article
author	Jae-Seung Yun Yong-Moon Park Kyungdo Han Hyung-Wook Kim Seon-Ah Cha Yu-Bae Ahn Seung-Hyun Ko
author_facet	Jae-Seung Yun Yong-Moon Park Kyungdo Han Hyung-Wook Kim Seon-Ah Cha Yu-Bae Ahn Seung-Hyun Ko
author_sort	Jae-Seung Yun
title	Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
title_short	Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
title_full	Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
title_fullStr	Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
title_full_unstemmed	Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
title_sort	severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7f7f33cf952497d930d25d83b50e5ef
work_keys_str_mv	AT jaeseungyun severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes AT yongmoonpark severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes AT kyungdohan severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes AT hyungwookkim severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes AT seonahcha severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes AT yubaeahn severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes AT seunghyunko severehypoglycemiaandtheriskofendstagerenaldiseaseintype2diabetes
_version_	1718396329378447360

Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes

Ejemplares similares