The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.

The precise timing of events in the brain has consequences for intracellular processes, synaptic plasticity, integration and network behaviour. Pyramidal neurons, the most widespread excitatory neuron of the neocortex have multiple spike initiation zones, which interact via dendritic and somatic spi...

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Autores principales:	Debora Ledergerber, Matthew Evan Larkum
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7f9a452cbd342a6ba5158d3a0243e7a
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spelling	oai:doaj.org-article:f7f9a452cbd342a6ba5158d3a0243e7a2021-11-18T07:25:19ZThe time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.1932-620310.1371/journal.pone.0033146https://doaj.org/article/f7f9a452cbd342a6ba5158d3a0243e7a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427971/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The precise timing of events in the brain has consequences for intracellular processes, synaptic plasticity, integration and network behaviour. Pyramidal neurons, the most widespread excitatory neuron of the neocortex have multiple spike initiation zones, which interact via dendritic and somatic spikes actively propagating in all directions within the dendritic tree. For these neurons, therefore, both the location and timing of synaptic inputs are critical. The time window for which the backpropagating action potential can influence dendritic spike generation has been extensively studied in layer 5 neocortical pyramidal neurons of rat somatosensory cortex. Here, we re-examine this coincidence detection window for pyramidal cell types across the rat somatosensory cortex in layers 2/3, 5 and 6. We find that the time-window for optimal interaction is widest and shifted in layer 5 pyramidal neurons relative to cells in layers 6 and 2/3. Inputs arriving at the same time and locations will therefore differentially affect spike-timing dependent processes in the different classes of pyramidal neurons.Debora LedergerberMatthew Evan LarkumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33146 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Debora Ledergerber Matthew Evan Larkum The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.
description	The precise timing of events in the brain has consequences for intracellular processes, synaptic plasticity, integration and network behaviour. Pyramidal neurons, the most widespread excitatory neuron of the neocortex have multiple spike initiation zones, which interact via dendritic and somatic spikes actively propagating in all directions within the dendritic tree. For these neurons, therefore, both the location and timing of synaptic inputs are critical. The time window for which the backpropagating action potential can influence dendritic spike generation has been extensively studied in layer 5 neocortical pyramidal neurons of rat somatosensory cortex. Here, we re-examine this coincidence detection window for pyramidal cell types across the rat somatosensory cortex in layers 2/3, 5 and 6. We find that the time-window for optimal interaction is widest and shifted in layer 5 pyramidal neurons relative to cells in layers 6 and 2/3. Inputs arriving at the same time and locations will therefore differentially affect spike-timing dependent processes in the different classes of pyramidal neurons.
format	article
author	Debora Ledergerber Matthew Evan Larkum
author_facet	Debora Ledergerber Matthew Evan Larkum
author_sort	Debora Ledergerber
title	The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.
title_short	The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.
title_full	The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.
title_fullStr	The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.
title_full_unstemmed	The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.
title_sort	time window for generation of dendritic spikes by coincidence of action potentials and epsps is layer specific in somatosensory cortex.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f7f9a452cbd342a6ba5158d3a0243e7a
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The time window for generation of dendritic spikes by coincidence of action potentials and EPSPs is layer specific in somatosensory cortex.

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