Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma

Cervical squamous cell carcinoma is one of the most common causes of female cancer deaths worldwide. At present, immunotherapy using immune checkpoint blockade (ICB) has improved the prognosis of many cancer patients, and neoantigens generated by mutations may serve as potential biomarkers for predi...

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Autores principales:	Fang Wen, Shuai Ruan, Wenjie Huang, Xiaoxue Chen, Yulan Wang, Suping Gu, Jiatong Liu, Shenlin Liu, Peng Shu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tumor mutation burden immune infiltration prognosis cervical squamous cell carcinoma TCGA Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7fabf8f6eef4f95a74dfcc87a59ed5f
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spelling	oai:doaj.org-article:f7fabf8f6eef4f95a74dfcc87a59ed5f2021-11-11T06:27:23ZPrognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma2296-858X10.3389/fmed.2021.755657https://doaj.org/article/f7fabf8f6eef4f95a74dfcc87a59ed5f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.755657/fullhttps://doaj.org/toc/2296-858XCervical squamous cell carcinoma is one of the most common causes of female cancer deaths worldwide. At present, immunotherapy using immune checkpoint blockade (ICB) has improved the prognosis of many cancer patients, and neoantigens generated by mutations may serve as potential biomarkers for predicting the outcome of ICB therapy. In this study, we identified missense mutations as the most frequent in landscapes of gene mutation in cervical squamous cell carcinoma (CESC) samples. Patients with higher tumor mutation burden (TMB) presented higher overall survival (OS). In addition, there was a significant correlation between the high TMB group and fractions of most immune cells. Univariate and multivariate Cox regression analyses identified five hub genes (IFNG, SERPINA3, CCL4L2, TNFSF15, and IL1R1) that were used to build a prognostic model. In the prognostic model, the low-risk group achieved better OS. Mutations in the five hub genes mainly affected the infiltration level of CD8+ T cells and dendritic cells. In conclusion, our study is valuable for exploring the role of TMB and its relationship with immune infiltration in CESC. Moreover, the prognosis model may help predict the sensitivity of patients to immunotherapy and provide underlying biomarkers for personalized immunotherapy.Fang WenFang WenFang WenShuai RuanShuai RuanShuai RuanWenjie HuangWenjie HuangWenjie HuangXiaoxue ChenXiaoxue ChenXiaoxue ChenYulan WangYulan WangYulan WangSuping GuSuping GuSuping GuJiatong LiuJiatong LiuJiatong LiuShenlin LiuShenlin LiuShenlin LiuPeng ShuPeng ShuPeng ShuFrontiers Media S.A.articletumor mutation burdenimmune infiltrationprognosiscervical squamous cell carcinomaTCGAMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor mutation burden immune infiltration prognosis cervical squamous cell carcinoma TCGA Medicine (General) R5-920
spellingShingle	tumor mutation burden immune infiltration prognosis cervical squamous cell carcinoma TCGA Medicine (General) R5-920 Fang Wen Fang Wen Fang Wen Shuai Ruan Shuai Ruan Shuai Ruan Wenjie Huang Wenjie Huang Wenjie Huang Xiaoxue Chen Xiaoxue Chen Xiaoxue Chen Yulan Wang Yulan Wang Yulan Wang Suping Gu Suping Gu Suping Gu Jiatong Liu Jiatong Liu Jiatong Liu Shenlin Liu Shenlin Liu Shenlin Liu Peng Shu Peng Shu Peng Shu Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma
description	Cervical squamous cell carcinoma is one of the most common causes of female cancer deaths worldwide. At present, immunotherapy using immune checkpoint blockade (ICB) has improved the prognosis of many cancer patients, and neoantigens generated by mutations may serve as potential biomarkers for predicting the outcome of ICB therapy. In this study, we identified missense mutations as the most frequent in landscapes of gene mutation in cervical squamous cell carcinoma (CESC) samples. Patients with higher tumor mutation burden (TMB) presented higher overall survival (OS). In addition, there was a significant correlation between the high TMB group and fractions of most immune cells. Univariate and multivariate Cox regression analyses identified five hub genes (IFNG, SERPINA3, CCL4L2, TNFSF15, and IL1R1) that were used to build a prognostic model. In the prognostic model, the low-risk group achieved better OS. Mutations in the five hub genes mainly affected the infiltration level of CD8+ T cells and dendritic cells. In conclusion, our study is valuable for exploring the role of TMB and its relationship with immune infiltration in CESC. Moreover, the prognosis model may help predict the sensitivity of patients to immunotherapy and provide underlying biomarkers for personalized immunotherapy.
format	article
author	Fang Wen Fang Wen Fang Wen Shuai Ruan Shuai Ruan Shuai Ruan Wenjie Huang Wenjie Huang Wenjie Huang Xiaoxue Chen Xiaoxue Chen Xiaoxue Chen Yulan Wang Yulan Wang Yulan Wang Suping Gu Suping Gu Suping Gu Jiatong Liu Jiatong Liu Jiatong Liu Shenlin Liu Shenlin Liu Shenlin Liu Peng Shu Peng Shu Peng Shu
author_facet	Fang Wen Fang Wen Fang Wen Shuai Ruan Shuai Ruan Shuai Ruan Wenjie Huang Wenjie Huang Wenjie Huang Xiaoxue Chen Xiaoxue Chen Xiaoxue Chen Yulan Wang Yulan Wang Yulan Wang Suping Gu Suping Gu Suping Gu Jiatong Liu Jiatong Liu Jiatong Liu Shenlin Liu Shenlin Liu Shenlin Liu Peng Shu Peng Shu Peng Shu
author_sort	Fang Wen
title	Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma
title_short	Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma
title_full	Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma
title_fullStr	Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma
title_full_unstemmed	Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma
title_sort	prognostic value of tumor mutational burden related to immune infiltration in cervical squamous cell carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f7fabf8f6eef4f95a74dfcc87a59ed5f
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Prognostic Value of Tumor Mutational Burden Related to Immune Infiltration in Cervical Squamous Cell Carcinoma

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