Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study

Abstract Background Dyslipidemia is a major cardiovascular risk factor and common in diabetes patients. Most guidelines focus on optimal lipid levels, while variation of lipid profiles is far less discussed. This study aims to investigate the association of visit-to-visit variability in blood lipids...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mu-Cyun Wang, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Type 2 diabetes Blood lipid variability All-cause mortality Cardiovascular mortality Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/f7fb11b42e084e9eb331e3cc6903f3a8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7fb11b42e084e9eb331e3cc6903f3a8
record_format	dspace
spelling	oai:doaj.org-article:f7fb11b42e084e9eb331e3cc6903f3a82021-11-28T12:14:09ZEffect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study10.1186/s12933-021-01421-41475-2840https://doaj.org/article/f7fb11b42e084e9eb331e3cc6903f3a82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12933-021-01421-4https://doaj.org/toc/1475-2840Abstract Background Dyslipidemia is a major cardiovascular risk factor and common in diabetes patients. Most guidelines focus on optimal lipid levels, while variation of lipid profiles is far less discussed. This study aims to investigate the association of visit-to-visit variability in blood lipids with all-cause, cardiovascular, and non-cardiovascular mortality in patients with type 2 diabetes. Methods We identified 10,583 type 2 diabetes patients aged ≥ 30 years with follow-up ≥ 3 years and who participated in the Diabetes Care Management Program at a medical center in Taiwan. Variability in lipid profiles within 3 years after entry was calculated using coefficient of variation. Cox proportional hazard models were used to evaluate lipid variability in relation to subsequent mortality. Results Over a mean follow-up of 6.4 years, 1838 all-cause deaths (809 cardiovascular deaths) were observed. For each 10% increase in variability in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol, the hazard ratios (95% confidence intervals) of all-cause mortality were 1.30 (1.22–1.37), 1.05 (1.01–1.09), and 1.10 (1.03–1.16), respectively; those of cardiovascular mortality were 1.27 (1.16–1.39), 1.08 (1.02–1.15), and 1.16 (1.07–1.27), respectively. Each 10% increase in high-density lipoprotein cholesterol variability conveyed 31% greater risk of non-cardiovascular mortality. High variability in total cholesterol and low-density lipoprotein cholesterol increased all-cause mortality in subgroups of nonsmoking, regular exercising, non-dyslipidemia, and more severe status of diabetes at baseline. Conclusions Blood lipid variability except for triglyceride variability was associated with all-cause and cardiovascular mortality in patients with type 2 diabetes.Mu-Cyun WangChia-Ing LiChiu-Shong LiuChih-Hsueh LinShing-Yu YangTsai-Chung LiCheng-Chieh LinBMCarticleType 2 diabetesBlood lipid variabilityAll-cause mortalityCardiovascular mortalityDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes Blood lipid variability All-cause mortality Cardiovascular mortality Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Type 2 diabetes Blood lipid variability All-cause mortality Cardiovascular mortality Diseases of the circulatory (Cardiovascular) system RC666-701 Mu-Cyun Wang Chia-Ing Li Chiu-Shong Liu Chih-Hsueh Lin Shing-Yu Yang Tsai-Chung Li Cheng-Chieh Lin Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
description	Abstract Background Dyslipidemia is a major cardiovascular risk factor and common in diabetes patients. Most guidelines focus on optimal lipid levels, while variation of lipid profiles is far less discussed. This study aims to investigate the association of visit-to-visit variability in blood lipids with all-cause, cardiovascular, and non-cardiovascular mortality in patients with type 2 diabetes. Methods We identified 10,583 type 2 diabetes patients aged ≥ 30 years with follow-up ≥ 3 years and who participated in the Diabetes Care Management Program at a medical center in Taiwan. Variability in lipid profiles within 3 years after entry was calculated using coefficient of variation. Cox proportional hazard models were used to evaluate lipid variability in relation to subsequent mortality. Results Over a mean follow-up of 6.4 years, 1838 all-cause deaths (809 cardiovascular deaths) were observed. For each 10% increase in variability in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol, the hazard ratios (95% confidence intervals) of all-cause mortality were 1.30 (1.22–1.37), 1.05 (1.01–1.09), and 1.10 (1.03–1.16), respectively; those of cardiovascular mortality were 1.27 (1.16–1.39), 1.08 (1.02–1.15), and 1.16 (1.07–1.27), respectively. Each 10% increase in high-density lipoprotein cholesterol variability conveyed 31% greater risk of non-cardiovascular mortality. High variability in total cholesterol and low-density lipoprotein cholesterol increased all-cause mortality in subgroups of nonsmoking, regular exercising, non-dyslipidemia, and more severe status of diabetes at baseline. Conclusions Blood lipid variability except for triglyceride variability was associated with all-cause and cardiovascular mortality in patients with type 2 diabetes.
format	article
author	Mu-Cyun Wang Chia-Ing Li Chiu-Shong Liu Chih-Hsueh Lin Shing-Yu Yang Tsai-Chung Li Cheng-Chieh Lin
author_facet	Mu-Cyun Wang Chia-Ing Li Chiu-Shong Liu Chih-Hsueh Lin Shing-Yu Yang Tsai-Chung Li Cheng-Chieh Lin
author_sort	Mu-Cyun Wang
title	Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
title_short	Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
title_full	Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
title_fullStr	Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
title_full_unstemmed	Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
title_sort	effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/f7fb11b42e084e9eb331e3cc6903f3a8
work_keys_str_mv	AT mucyunwang effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy AT chiaingli effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy AT chiushongliu effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy AT chihhsuehlin effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy AT shingyuyang effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy AT tsaichungli effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy AT chengchiehlin effectofbloodlipidvariabilityonmortalityinpatientswithtype2diabetesalargesinglecentercohortstudy
_version_	1718408176196386816

Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study

Ejemplares similares