5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

The authors show that resistance to the antifungal 5-fluorocytosine in Cryptococcus deuterogattii is acquired more frequently in isolates with elevated mutation rate, and is associated with alterations in capsule biosynthesis and nucleotide metabolism.

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Autores principales:	R. Blake Billmyre, Shelly Applen Clancey, Lucy X. Li, Tamara L. Doering, Joseph Heitman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7fc4a07b3e44f9382953de7b6a59040
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spelling	oai:doaj.org-article:f7fc4a07b3e44f9382953de7b6a590402021-12-02T15:33:32Z5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus10.1038/s41467-019-13890-z2041-1723https://doaj.org/article/f7fc4a07b3e44f9382953de7b6a590402020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13890-zhttps://doaj.org/toc/2041-1723The authors show that resistance to the antifungal 5-fluorocytosine in Cryptococcus deuterogattii is acquired more frequently in isolates with elevated mutation rate, and is associated with alterations in capsule biosynthesis and nucleotide metabolism.R. Blake BillmyreShelly Applen ClanceyLucy X. LiTamara L. DoeringJoseph HeitmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. Blake Billmyre Shelly Applen Clancey Lucy X. Li Tamara L. Doering Joseph Heitman 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
description	The authors show that resistance to the antifungal 5-fluorocytosine in Cryptococcus deuterogattii is acquired more frequently in isolates with elevated mutation rate, and is associated with alterations in capsule biosynthesis and nucleotide metabolism.
format	article
author	R. Blake Billmyre Shelly Applen Clancey Lucy X. Li Tamara L. Doering Joseph Heitman
author_facet	R. Blake Billmyre Shelly Applen Clancey Lucy X. Li Tamara L. Doering Joseph Heitman
author_sort	R. Blake Billmyre
title	5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
title_short	5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
title_full	5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
title_fullStr	5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
title_full_unstemmed	5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus
title_sort	5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in cryptococcus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f7fc4a07b3e44f9382953de7b6a59040
work_keys_str_mv	AT rblakebillmyre 5fluorocytosineresistanceisassociatedwithhypermutationandalterationsincapsulebiosynthesisincryptococcus AT shellyapplenclancey 5fluorocytosineresistanceisassociatedwithhypermutationandalterationsincapsulebiosynthesisincryptococcus AT lucyxli 5fluorocytosineresistanceisassociatedwithhypermutationandalterationsincapsulebiosynthesisincryptococcus AT tamaraldoering 5fluorocytosineresistanceisassociatedwithhypermutationandalterationsincapsulebiosynthesisincryptococcus AT josephheitman 5fluorocytosineresistanceisassociatedwithhypermutationandalterationsincapsulebiosynthesisincryptococcus
_version_	1718387121130045440

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

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