A dynamical model of genetic networks for cell differentiation.

A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a...

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Autores principales:	Marco Villani, Alessia Barbieri, Roberto Serra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7fd6732b49246239ae3a0ff2064cde9
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spelling	oai:doaj.org-article:f7fd6732b49246239ae3a0ff2064cde92021-11-18T06:57:05ZA dynamical model of genetic networks for cell differentiation.1932-620310.1371/journal.pone.0017703https://doaj.org/article/f7fd6732b49246239ae3a0ff2064cde92011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21464974/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.Marco VillaniAlessia BarbieriRoberto SerraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e17703 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marco Villani Alessia Barbieri Roberto Serra A dynamical model of genetic networks for cell differentiation.
description	A mathematical model is proposed which is able to describe the most important features of cell differentiation, without requiring specific detailed assumptions concerning the interactions which drive the phenomenon. On the contrary, cell differentiation is described here as an emergent property of a generic model of the underlying gene regulatory network, and it can therefore be applied to a variety of different organisms. The model points to a peculiar role of cellular noise in differentiation and leads to non trivial predictions which could be subject to experimental testing. Moreover, a single model proves able to describe several different phenomena observed in various differentiation processes.
format	article
author	Marco Villani Alessia Barbieri Roberto Serra
author_facet	Marco Villani Alessia Barbieri Roberto Serra
author_sort	Marco Villani
title	A dynamical model of genetic networks for cell differentiation.
title_short	A dynamical model of genetic networks for cell differentiation.
title_full	A dynamical model of genetic networks for cell differentiation.
title_fullStr	A dynamical model of genetic networks for cell differentiation.
title_full_unstemmed	A dynamical model of genetic networks for cell differentiation.
title_sort	dynamical model of genetic networks for cell differentiation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/f7fd6732b49246239ae3a0ff2064cde9
work_keys_str_mv	AT marcovillani adynamicalmodelofgeneticnetworksforcelldifferentiation AT alessiabarbieri adynamicalmodelofgeneticnetworksforcelldifferentiation AT robertoserra adynamicalmodelofgeneticnetworksforcelldifferentiation AT marcovillani dynamicalmodelofgeneticnetworksforcelldifferentiation AT alessiabarbieri dynamicalmodelofgeneticnetworksforcelldifferentiation AT robertoserra dynamicalmodelofgeneticnetworksforcelldifferentiation
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A dynamical model of genetic networks for cell differentiation.

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