Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice

Abstract Laboratory mice are typically housed in “shoebox" cages that limit the expression of natural behaviours. Temporary access to more complex environments (playpens) may improve their welfare. We aimed to assess if access to playpens is rewarding for conventionally-housed mice and to docum...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anna S. Ratuski, I. Joanna Makowska, Kaitlyn R. Dvorack, Daniel M. Weary
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7fe31f166544566a76d29431b698a0c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7fe31f166544566a76d29431b698a0c
record_format	dspace
spelling	oai:doaj.org-article:f7fe31f166544566a76d29431b698a0c2021-12-02T18:48:09ZUsing approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice10.1038/s41598-021-98356-32045-2322https://doaj.org/article/f7fe31f166544566a76d29431b698a0c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98356-3https://doaj.org/toc/2045-2322Abstract Laboratory mice are typically housed in “shoebox" cages that limit the expression of natural behaviours. Temporary access to more complex environments (playpens) may improve their welfare. We aimed to assess if access to playpens is rewarding for conventionally-housed mice and to document mouse behaviour during playpen access. Female C57BL/6J, BALB/cJ, and DBA/2J mice were provided temporary access to a large enriched playpen three times per week; control mice remained in their home cages. We measured latency to enter playpens and anticipatory behaviour to determine if access was rewarding, and recorded mouse behaviour during playpen sessions. Over time, playpen mice entered the playpen more quickly; latency declined from 168 ± 22 to 13 ± 2 s over the 14-d trial. As expected, playpen mice showed an increase in anticipatory behaviour before playpen access (mean ± SE = 19.7 ± 2.6 behavioural transitions), while control mice showed no change in anticipatory behaviour relative to baseline values (2.4 ± 1.6 transitions). Mice in the playpen performed more ambulatory behaviours than control mice who remained in home cages (21.5 ± 0.7 vs 6.9 ± 1.1 observations of 25 total observations). We conclude that conventionally-housed mice find voluntary playpen access rewarding, and suggest this as a useful option for providing laboratory mice with access to more complex environments.Anna S. RatuskiI. Joanna MakowskaKaitlyn R. DvorackDaniel M. WearyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna S. Ratuski I. Joanna Makowska Kaitlyn R. Dvorack Daniel M. Weary Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
description	Abstract Laboratory mice are typically housed in “shoebox" cages that limit the expression of natural behaviours. Temporary access to more complex environments (playpens) may improve their welfare. We aimed to assess if access to playpens is rewarding for conventionally-housed mice and to document mouse behaviour during playpen access. Female C57BL/6J, BALB/cJ, and DBA/2J mice were provided temporary access to a large enriched playpen three times per week; control mice remained in their home cages. We measured latency to enter playpens and anticipatory behaviour to determine if access was rewarding, and recorded mouse behaviour during playpen sessions. Over time, playpen mice entered the playpen more quickly; latency declined from 168 ± 22 to 13 ± 2 s over the 14-d trial. As expected, playpen mice showed an increase in anticipatory behaviour before playpen access (mean ± SE = 19.7 ± 2.6 behavioural transitions), while control mice showed no change in anticipatory behaviour relative to baseline values (2.4 ± 1.6 transitions). Mice in the playpen performed more ambulatory behaviours than control mice who remained in home cages (21.5 ± 0.7 vs 6.9 ± 1.1 observations of 25 total observations). We conclude that conventionally-housed mice find voluntary playpen access rewarding, and suggest this as a useful option for providing laboratory mice with access to more complex environments.
format	article
author	Anna S. Ratuski I. Joanna Makowska Kaitlyn R. Dvorack Daniel M. Weary
author_facet	Anna S. Ratuski I. Joanna Makowska Kaitlyn R. Dvorack Daniel M. Weary
author_sort	Anna S. Ratuski
title	Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
title_short	Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
title_full	Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
title_fullStr	Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
title_full_unstemmed	Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
title_sort	using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7fe31f166544566a76d29431b698a0c
work_keys_str_mv	AT annasratuski usingapproachlatencyandanticipatorybehaviourtoassesswhethervoluntaryplaypenaccessisrewardingtolaboratorymice AT ijoannamakowska usingapproachlatencyandanticipatorybehaviourtoassesswhethervoluntaryplaypenaccessisrewardingtolaboratorymice AT kaitlynrdvorack usingapproachlatencyandanticipatorybehaviourtoassesswhethervoluntaryplaypenaccessisrewardingtolaboratorymice AT danielmweary usingapproachlatencyandanticipatorybehaviourtoassesswhethervoluntaryplaypenaccessisrewardingtolaboratorymice
_version_	1718377658941702144

Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice

Ejemplares similares